Benzenebutanol, b-amino-4-octyl-

Base Information

• Chemical Name: Benzenebutanol, b-amino-4-octyl-
• CAS No.: 177260-59-2
• Molecular Formula: C18H31NO
• Molecular Weight: 277.45
• Mol file: 177260-59-2.mol

Synonyms:

Chemical Property of Benzenebutanol, b-amino-4-octyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanol, b-amino-4-octyl-

There total 6 articles about Benzenebutanol, b-amino-4-octyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

1-octyl-4-vinylbenzene (46745-66-8) + ethanolamine (141-43-5) → 2-amino-2-(4-octylphenethyl)-4-(4-octylphenyl)butan-1-ol + 2-amino-4-(4-octylphenyl)butanol (177260-59-2)

Guidance literature:

With 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; tetrabutylammoniun azide; In N,N-dimethyl-formamide; at 25 - 26 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c07401

Reference yield: 13.0%

1-octyl-4-vinylbenzene (46745-66-8) + ethanolamine (141-43-5) + Diethyl vinylphosphonate (682-30-4) → diethyl (RS)-(3-amino-3-(hydroxymethyl)-5-(4-octylphenyl)pentyl)phosphonate + 2-amino-2-(4-octylphenethyl)-4-(4-octylphenyl)butan-1-ol + 2-amino-4-(4-octylphenyl)butanol (177260-59-2)

Guidance literature:

ethanolamine; Diethyl vinylphosphonate; With 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; tetrabutylammoniun azide; In N,N-dimethyl-formamide; at 25 - 26 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

1-octyl-4-vinylbenzene; With 3,5-difluoro-2,4,6-tris(N-phenylanilino)benzonitrile; In N,N-dimethyl-formamide; at 25 - 26 ℃; for 20h; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1021/jacs.1c07401

Reference yield:

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate (162358-08-9) → 2-amino-4-(4-octylphenyl)butanol (177260-59-2)

Guidance literature:

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate; With hydrogenchloride; In methanol; for 2h; Heating;

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/j.bmcl.2005.07.057

upstream raw materials:

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate

Octylbenzene

α-bromomethyl p(n-octyl)phenyl cetone

2-(acetylamino)-2-[2-(4-octylphenyl)-2-oxo-ethyl]propanedioic acid diethyl ester

Downstream raw materials:

2-[(S)-α-methoxy-α-trifluoromethylphenylacetylamino]-4-(4-octylphenyl)butanol

2-[(R)-α-methoxy-α-trifluoromethylphenylacetylamino]-4-(4-octylphenyl)butanol

[1-(di-tert-butoxy-thiophosphoryloxymethyl)-3-(4-octyl-phenyl)-propyl]-carbamic acid tert-butyl ester

[1-(di-tert-butoxy-phosphoryloxymethyl)-3-(4-octyl-phenyl)-propyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Foss Jr., Frank W.,Clemens, Jeremy J.,Davis, Michael D.,Snyder, Ashley H.,Zigler, Molly A.,Lynch, Kevin R.,Macdonald, Timothy L.. "Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors". . p. 4470 - 4474. Retrieved 2007/10/03.