Ethyl (2-methylphenoxy)acetate

Base Information

• Chemical Name: Ethyl (2-methylphenoxy)acetate
• CAS No.: 93917-68-1
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• European Community (EC) Number: 299-846-3
• DSSTox Substance ID: DTXSID30239881
• Nikkaji Number: J59.923I
• Wikidata: Q83122409
• Mol file: 93917-68-1.mol

Synonyms:Ethyl (2-methylphenoxy)acetate;93917-68-1;ethyl 2-(2-methylphenoxy)acetate;ethyl 2-(o-tolyloxy)acetate;EINECS 299-846-3;Ethyl 2-methylphenoxyacetate;Ethyl(2-methylphenoxy)acetate;ethyl-(2-methylphenoxy)acetate;SCHEMBL2871937;ethyl ((2-methylphenoxy)acetate;?Ethyl (2-methylphenoxy)acetate;DTXSID30239881;o-Tolyloxyacetic acid ethyl ester;NHFQSFIBSJPLIW-UHFFFAOYSA-N;o-tolyloxy-acetic acid ethyl ester;MFCD00216559;STK506758;AKOS003658788;Ethyl (2-methylphenoxy)acetate, 99%;2-Methylphenoxy-acetic acid ethyl ester;AS-62284;CS-0319013;FT-0642253;D86261;A844736

Chemical Property of Ethyl (2-methylphenoxy)acetate

Chemical Property:

• Vapor Pressure: 0.00962mmHg at 25°C
• Refractive Index: n20/D 1.503(lit.)
• Boiling Point: 264.6°Cat760mmHg
• Flash Point: 105.2°C
• PSA: 35.53000
• Density: 1.063g/cm³
• LogP: 1.93690
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

Ethyl (2-methylphenoxy)acetate 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=CC=C1C

Technology Process of Ethyl (2-methylphenoxy)acetate

There total 9 articles about Ethyl (2-methylphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl bromoacetate (105-36-2) + ortho-cresol (95-48-7,77504-84-8) → ethyl (2-methylphenoxy)acetate (93917-68-1)

Guidance literature:

ortho-cresol; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

ethyl bromoacetate; In acetonitrile; at 90 ℃; for 14h;

DOI:10.1021/acs.orglett.7b00386

Reference yield: 88.0%

chloroacetic acid ethyl ester (105-39-5) + ortho-cresol (95-48-7,77504-84-8) → ethyl (2-methylphenoxy)acetate (93917-68-1)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Reflux;

DOI:10.1016/j.biopha.2017.08.105

Reference yield: 85.7%

→ ethyl (2-methylphenoxy)acetate (93917-68-1)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; for 12h; Reflux;

upstream raw materials:

ethanol

o-methylphenoxyacetic acid

chloroacetic acid ethyl ester

sodium o-cresolate

Downstream raw materials:

ethyl 2-(4-chloro-2-methylphenoxy)acetate

isooctyl 2-methyl-4-chlorophenoxyacetate

ethyl 2,3-dihydro-1-benzofuran-2-carboxylate

N-o-tolyloxyacetyl-hydrazinecarbodithioic acid

Refernces

• 1、 -. "Anti-angiogenesis compound". Page/Page column 8; 9. . Retrieved 2021/03/24.
• 2、 Ji, Chang,Kelcher, Austin R.,Olivares, Jacob A.,Simon, Tamir,Vasquez, Antonio. "The Role of Oxygen in the Electrochemical Reduction of Ethyl 2-(2-(Bromomethyl)phenoxy)acetate at Carbon Cathodes in Dimethylformamide". . . Retrieved 2020/04/24.