N-ETHYL-N-(4-PICOLYL)ATROPAMIDE

Base Information

• Chemical Name: N-ETHYL-N-(4-PICOLYL)ATROPAMIDE
• CAS No.: 57322-50-6
• Molecular Formula: C17H18 N2 O
• Molecular Weight: 266.343
• Hs Code.: 2933399090
• Mol file: 57322-50-6.mol

Synonyms:Apotropicamide

Chemical Property of N-ETHYL-N-(4-PICOLYL)ATROPAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 492.042ºC at 760 mmHg
• Flash Point: 251.378ºC
• PSA: 33.20000
• Density: 1.096g/cm3
• LogP: 3.14350
• Storage Temp.: Amber Vial, Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Ethyl-N-(4-picolyl)atropamide ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 13-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Ethyl-N-(4-picolyl)atropamide is a major impurity of Tropicamide (T892650), a medication used to dilate the pupil.

Technology Process of N-ETHYL-N-(4-PICOLYL)ATROPAMIDE

There total 3 articles about N-ETHYL-N-(4-PICOLYL)ATROPAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

carbon monoxide (201230-82-2) + 1-phenyl-1-iodoethylene (51246-20-9) + 4-(ETHYLAMINOMETHYL)PYRIDINE (33403-97-3) → N-ethyl-N-(4-picolyl)-atropamide (57322-50-6)

Guidance literature:

With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 50 ℃; for 20h; under 750.075 Torr; Time; chemospecific reaction; Autoclave; Inert atmosphere;

DOI:10.1016/j.tet.2013.11.087

Reference yield:

tropicamide (1508-75-4,92934-63-9) → 2-phenylacrylic acid (492-38-6) + Tropic acid (529-64-6,28845-94-5) + N-ethyl-N-(4-picolyl)-atropamide (57322-50-6) + 4-(ETHYLAMINOMETHYL)PYRIDINE (33403-97-3)

Guidance literature:

With sodium hydroxide; In water; for 10h; Heating;

Reference yield:

→ N-ethyl-N-(4-picolyl)-atropamide (57322-50-6)

Guidance literature:

Atropasaeurechlorid, γ-Picolylethylamid;

upstream raw materials:

tropicamide

carbon monoxide

1-phenyl-1-iodoethylene

4-(ETHYLAMINOMETHYL)PYRIDINE

Refernces

• 1、 Pohloudek-Fabini,Martin,Gallasch. "Contribution to the stability of tropicamide solutions (author's transl)". . p. 184 - 187. Retrieved 2007/10/02.