3-Pyridinecarboxylic acid, 2-[[[2-[methyl(2-methylpropyl)amino]phenyl]methyl]thio]-

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 2-[[[2-[methyl(2-methylpropyl)amino]phenyl]methyl]thio]-
• CAS No.: 181824-24-8
• Molecular Formula: C₁₈H₂₂N₂O₂S
• Molecular Weight: 330.451
• Mol file: 181824-24-8.mol

Synonyms:

Chemical Property of 3-Pyridinecarboxylic acid, 2-[[[2-[methyl(2-methylpropyl)amino]phenyl]methyl]thio]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 2-[[[2-[methyl(2-methylpropyl)amino]phenyl]methyl]thio]-

There total 1 articles about 3-Pyridinecarboxylic acid, 2-[[[2-[methyl(2-methylpropyl)amino]phenyl]methyl]thio]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-carboxy-2-mercaptopyridine (38521-46-9) + 2-(N-isobutyl-N-methylamino)benzyl chloride hydrochloride → 2-[2-(Isobutyl-methyl-amino)-benzylsulfanyl]-nicotinic acid (181824-24-8)

Guidance literature:

With triethylamine;

DOI:10.1248/cpb.45.1177

Reference yield:

2-[2-(Isobutyl-methyl-amino)-benzylsulfanyl]-nicotinic acid (181824-24-8) → 2-[2-(Isobutyl-methyl-amino)-phenylmethanesulfinyl]-N-pyridin-4-yl-nicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride

2: 49 percent / m-chloroperbenzoic acid / CH₂Cl₂

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1248/cpb.45.1177

upstream raw materials:

3-carboxy-2-mercaptopyridine

Refernces