(1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid

Base Information Edit

Chemical Name:(1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid
CAS No.:261165-05-3
Molecular Formula:C11H19NO4
Molecular Weight:229.276
Hs Code.:29223900
European Community (EC) Number:695-099-6,851-929-0
DSSTox Substance ID:DTXSID301145654
Wikidata:Q76139646
Mol file:261165-05-3.mol

Synonyms:261165-05-3;(1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid;(+)-(1S,3R)-N-Boc-3-aminocyclopentanecarboxylic acid;(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid;(1S,3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopentane-1-carboxylic acid;410090-37-8;(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid;(1S,3R)-3-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylic acid;(1S,3R)-N-Boc-3-Aminocyclopentanecarboxylic acid;MFCD01320857;CIS-3-(BOC-AMINO)CYCLOPENTANE-1-CARBOXYLIC ACID;(1S,3R)-3-Boc-amino-cyclopentanecarboxylic acid;(1S,3R)-3-(Boc-amino)cyclopentanecarboxylic Acid;(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic acid;(1S,3R)-3-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylic acid;MFCD09992879;cis-3-Boc-amino-cyclopentanecarboxylic acid;cis-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic acid;SCHEMBL182101;(+)-(1S,3R)-N-Boc-3-aminocyclopentane carboxylic acid;BOC-D-CIS-NH(3)CPEN-OH;DTXSID301145654;(1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylicacid;AMY21640;(1S,3R)-3-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid;AKOS015948710;AC-7962;CS-W006202;SS-4383;B4397;EN300-185791;EN300-713795;P17289;A873174;A877366;J-500337;(1S,3R)-(+)-3-(bocamino)cyclopentanecarboxylicacid;(1s,3r)-n-boc-1-aminocyclopentane-3-carboxylic acid;(+)-(1r,3s)-n-boc-aminocyclopentane-3-carboxylic acid;(+)-(1r, 3s)-n-boc-aminocyclopentane-3-carboxylic acid;(1S,3R)-3-tert-butoxycarbonylamino-cyclopentanecarboxylic acid;(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentane carboxylic acid;(1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid, >=96.0% (HPLC);(1S,3R)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopentanecarboxylic acid;cis(1S,3R)-3-((tert-butoxycarbonyl)amino) cyclopentanecarboxylic acid;rac-(1R,3S)-3-{[(tert-butoxy)carbonyl]amino}cyclopentane-1-carboxylic acid;Cyclopentanecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,3R)-

Suppliers and Price of (1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylicAcid
50mg
$ 55.00

TCI Chemical
(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid >95.0%(GC)(T)
200mg
$ 99.00

SynQuest Laboratories
(1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-Boc protected
250 mg
$ 230.00

SynQuest Laboratories
(1S,3R)-(+)-3-Aminocyclopentane-1-carboxylic acid, N-Boc protected
1 g
$ 625.00

Sigma-Aldrich
(1S,3R)-(+)-3-(Boc-amino)cyclopentanecarboxylic acid ≥96.0% (HPLC)
500mg
$ 598.00

Matrix Scientific
(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid 95%
1g
$ 142.00

Matrix Scientific
(1S,3R)-Boc-3-aminocyclopentane-1 carboxylic acid 95%
250mg
$ 88.00

Crysdot
(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid 97%
25g
$ 1179.00

Crysdot
(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid 97%
10g
$ 634.00

Crysdot
(1S,3R)-3-(tert-Butoxycarbonylamino)cyclopentanecarboxylic Acid 97%
5g
$ 366.00

Total 38 raw suppliers

Chemical Property of (1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid Edit

Chemical Property:

Appearance/Colour:white powder or chunks
Vapor Pressure:6.55E-07mmHg at 25°C
Melting Point:110-114 °C
Refractive Index:1.4490 (estimate)
Boiling Point:382.5 °C at 760 mmHg
PKA:4.62±0.40(Predicted)
Flash Point:185.1 °C
PSA：75.63000
Density:1.15 g/cm³
LogP:2.15530
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:slightly sol. in Methanol
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:229.13140809
Heavy Atom Count:16
Complexity:282

Purity/Quality:

98%,99%, ^*data from raw suppliers

(-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCC(C1)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H]1CC[C@@H](C1)C(=O)O
Uses (-)-(1R,3S)-N-Boc-1-Aminocyclopentane-3-carboxylic Acid is a reagent used in the synthesis of 3-substituted aminocyclopentanes as potent NR2B subtype-sellective NMDA antagonists in the treatment of neuropathic pain and Parkinson’s.

Technology Process of (1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid

There total 2 articles about (1S,3R)-3-((tert-Butoxycarbonyl)amino)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21472-89-9
1-azabicyclo[2.2.1]heptan-3-one

: 261165-05-3
(1S,3R)-3-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 4 h / Reflux

2.1: potassium carbonate / water; tetrahydrofuran / 0 °C

2.2: 20 h / 20 °C

2.3: pH 4 - 5

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; water;