2-Fluoroethyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: 2-Fluoroethyl 4-methylbenzenesulfonate
• CAS No.: 383-50-6
• Molecular Formula: C9H11FO3S
• Molecular Weight: 218.249
• Hs Code.: 2905590090
• Mol file: 383-50-6.mol

Synonyms:Ethanol,2-fluoro-, 4-methylbenzenesulfonate (9CI);Ethanol, 2-fluoro-,p-toluenesulfonate (6CI,8CI);1-Fluoro-2-(tosyloxy)ethane;2-Fluoroethyl 4-toluenesulfonate;2-Fluoroethyltosylate;4-Methylbenzenesulfonic acid 2-fluoroethyl ester;Fluoro(tosyloxy)ethane;NSC 82210;Toluene-4-sulfonic acid 2-fluoroethyl ester;p-Toluenesulfonic acid 2-fluoroethyl ester;

Chemical Property of 2-Fluoroethyl 4-methylbenzenesulfonate

Chemical Property:

• Appearance/Colour: colorless or light-yellow liquid
• Vapor Pressure: 0.000239mmHg at 25°C
• Refractive Index: 1.495
• Boiling Point: 335 °C at 760 mmHg
• Flash Point: 156.4 °C
• PSA: 51.75000
• Density: 1.241 g/cm³
• LogP: 2.75060
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-FluoroethylTosylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoroethyl Tosylate is an intermediate used in the preparation and pre-clinical evaluation of new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by positron emission tomography (PET) imaging.

Technology Process of 2-Fluoroethyl 4-methylbenzenesulfonate

There total 12 articles about 2-Fluoroethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoroethanol (371-62-0) + p-toluenesulfonyl chloride (98-59-9) → 2-fluoroethyl tosylate (383-50-6)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 17h;

Reference yield: 94.0%

2-fluoroethanol (371-62-0) + toluene-4-sulfonic acid (104-15-4) → 2-fluoroethyl tosylate (383-50-6)

Guidance literature:

With pyridine; at 0 ℃; for 3.5h;

Reference yield: 94.0%

→ 2-fluoroethyl tosylate (383-50-6)

Guidance literature:

upstream raw materials:

2-fluoroethanol

p-toluenesulfonyl chloride

p-toluenesulfonylanhydride

toluene-4-sulfonic acid

Downstream raw materials:

(S)-1-((R)-1-benzylpyrrolidin-3-yl)-N-(2-fluoroethyl)ethanamine

2-(chloro-5-methoxy-phenyl)(2-fluoroethyl)amine

N-(benzofuran-2-ylmethyl)-N'-(4-(2-fluoroethoxy)benzyl)homopiperazine

FE-PE₂I

Refernces

• 1、 Nordeman,Jayendra,Briard,Li,Larhed,Antoni,Estrada,Selvaraju,?berg,Jensen,St?lberg,Skogseid,Monazzam. "18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand". . . Retrieved 2021.
• 2、 Jia, Lina,Li, Xiao,Cheng, Dengfeng,Zhang, Lan. "Fluorine-18 click radiosynthesis and microPET/CT evaluation of a small peptide-a potential PET probe for carbonic anhydrase IX". . p. 785 - 789. Retrieved 2019.
• 3、 Denk, Christoph,Wilkovitsch, Martin,Skrinjar, Philipp,Svatunek, Dennis,Mairinger, Severin,Kuntner, Claudia,Filip, Thomas,Fr?hlich, Johannes,Wanek, Thomas,Mikula, Hannes. "Fluoroalkyl azides for rapid radiolabeling and (Re)investigation of their potential towards: In vivo click chemistry". . p. 5976 - 5982. Retrieved 2017.
• 4、 Depke, Dominic Alexej,Hermann, Sven,Konken, Christian Paul,Rentmeister, Andrea,R?sner, Lukas,Sch?fers, Michael. "A novel18F-labeled clickable substrate for targeted imaging of SNAP-tag expressing cells by PETin vivo". supporting information. p. 9850 - 9853. Retrieved 2021/10/08.