1-Hydroxy-1-cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-Hydroxy-1-cyclopropanecarboxylic acid
• CAS No.: 17994-25-1
• Molecular Formula: C4H6O3
• Molecular Weight: 102.09
• Hs Code.: 29181998
• European Community (EC) Number: 626-105-7
• DSSTox Substance ID: DTXSID90369774
• Nikkaji Number: J2.476.404D
• Wikidata: Q72483674
• Mol file: 17994-25-1.mol

Synonyms:1-Hydroxy-1-cyclopropanecarboxylic acid;17994-25-1;1-hydroxycyclopropane-1-carboxylic Acid;1-hydroxycyclopropanecarboxylic acid;Cyclopropanecarboxylic acid, 1-hydroxy-;MFCD00010797;1-hydroxy-cyclopropanecarboxylic acid;(1-hydroxy-1-cyclopropyl) carboxylic acid;SCHEMBL153693;DTXSID90369774;GQXURJDNDYACGE-UHFFFAOYSA-N;1-hydroxycyclopropanecaboxylic acid;1-hydroxycyclo-propanecarboxylic acid;1-hydroxycyclopropane-carboxylic acid;AC-497;BBL101795;STL555592;1-Hydroxy-1-cyclopropanecarboxylicacid;1-hydroxy-cyclopropane-carboxylic acid;AKOS000121170;hydroxy-1-cyclopropane carboxylic acid;AM85636;CS-W011313;PB47313;PS-9310;1-hydroxy-1-cyclopropane carboxylic acid;1-hydroxy-cyclopropane-1-carboxylic acid;SY097482;FT-0637637;H1664;1-Hydroxy-1-cyclopropanecarboxylic acid, 97%;EN300-25702;A18337;Z216340524

Chemical Property of 1-Hydroxy-1-cyclopropanecarboxylic acid

Chemical Property:

• Appearance/Colour: Beige fine crystalline powder
• Vapor Pressure: 0.000592mmHg at 25°C
• Melting Point: 108-110 °C(lit.)
• Refractive Index: 1.5130 (estimate)
• Boiling Point: 276.567 °C at 760 mmHg
• PKA: 3.94±0.20(Predicted)
• Flash Point: 135.307 °C
• PSA: 57.53000
• Density: 1.676 g/cm³
• LogP: -0.40410
• Storage Temp.: Refrigerator (+4°C)
• Solubility.: Chloroform+DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 102.031694049
• Heavy Atom Count: 7
• Complexity: 104

Purity/Quality:

98% ^*data from raw suppliers

1-Hydroxycyclopropanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38-34-22
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1(C(=O)O)O
• Uses: A hydroxycarboxylic acid as additive enhancing topical actions of therapeutic agents A hydroxycarboxylic acid as additive enhancing topical actions of therapeutic agents.

Technology Process of 1-Hydroxy-1-cyclopropanecarboxylic acid

There total 1 articles about 1-Hydroxy-1-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutane-1,2-dione (33689-28-0) → 1-Hydroxy-1-cyclopropanecarboxylic acid (17994-25-1)

Guidance literature:

With N-hydrochloric acid;

DOI:10.1016/S0040-4020(01)91969-6

Reference yield: 98.5%

methanol (67-56-1) + 1-Hydroxy-1-cyclopropanecarboxylic acid (17994-25-1) → 1-hydroxy-cyclopropanecarboxylic acid methyl ester (33689-29-1)

Guidance literature:

With thionyl chloride;

DOI:10.1016/S0040-4039(01)80131-3

Reference yield: 95.0%

1-Hydroxy-1-cyclopropanecarboxylic acid (17994-25-1) + diazodiphenylmethane (908093-98-1) → benzhydryl 1-hydroxycyclopropane-1-carboxylate

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2007.08.001

upstream raw materials:

cyclobutane-1,2-dione

Downstream raw materials:

1-hydroxy-cyclopropanecarboxylic acid methyl ester

1-(hydroxymethyl)cyclopropan-1-ol

propionic acid

cyclopropanone

Refernces