6-Chloropyridazin-3-ol

Base Information

• Chemical Name: 6-Chloropyridazin-3-ol
• CAS No.: 19064-67-6
• Molecular Formula: C4H3ClN2O
• Molecular Weight: 130.534
• Hs Code.: 2933990090
• Mol file: 19064-67-6.mol

Synonyms:6-chloropyridazin-3(2H)-one;3(2H)-Pyridazinone, 6-chloro-;3-Chloro-6-pyridazone;3-Hydroxy-6-chloropyridazine;

Chemical Property of 6-Chloropyridazin-3-ol

Chemical Property:

• Melting Point: 140.0 to 144.0 °C
• Refractive Index: 1.632
• PKA: 9.80±0.40(Predicted)
• PSA: 45.75000
• Density: 1.55 g/cm³
• LogP: 0.42330
• Storage Temp.: Room temperature.
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

6-Chloropyridazin-3(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloropyridazin-3(2h)-one (cas# 19064-67-6) is a useful research chemical.

Technology Process of 6-Chloropyridazin-3-ol

There total 16 articles about 6-Chloropyridazin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,6-dichlorpyridazine (141-30-0) → 6-chloro-2H-pyridazin-3-one (19064-67-6)

Guidance literature:

With acetic acid; for 3h; Heating;

DOI:10.1039/b713638b

Reference yield: 93.0%

C4H5ClN2O → 6-chloro-2H-pyridazin-3-one (19064-67-6)

Guidance literature:

With pyridine; oxygen; copper diacetate; sodium carbonate; In toluene; at 20 - 100 ℃; for 12h; chemoselective reaction;

DOI:10.1002/ejoc.201300640

Reference yield: 92.0%

3-chloro-6-methoxypyridazine (1722-10-7) → 3-chloro-6-hydroxypyridazine (19064-67-6)

Guidance literature:

With toluene-4-sulfonic acid; lithium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h;

DOI:10.1080/00397911.2010.493262

upstream raw materials:

3,6-dichlorpyridazine

acetic acid

Maleic hydrazide

3-chloro-6-(ethyloxy)pyridazine

Downstream raw materials:

2-[6-chloro-pyridazin-3(2H)-one-2-yl]-acetic acid

3,6-dichlorpyridazine

5-Amino-3-chloropyridazin-6(1H)-one

5-amino-6-chloro-3(2H)-pyridazinone

Refernces

• 1、 Steck. "-". . p. 1597. Retrieved 1959.
• 2、 -. "Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof". Paragraph 1866; 1868-1870. . Retrieved 2020/08/28.
• 3、 -. "Histone deacetylase inhibitor taking pyridazinone as mother nucleus structure, and preparation method and applications thereof". Paragraph 0124-0127. . Retrieved 2019/02/10.