Fotemustine

Base Information

• Chemical Name: Fotemustine
• CAS No.: 92118-27-9
• Molecular Formula: C₉H₁₉ClN₃O₅P
• Molecular Weight: 315.694
• European Community (EC) Number: 630-468-7
• UNII: GQ7JL9P5I2,UPB2NN83AR,QY93P3GN94
• DSSTox Substance ID: DTXSID80869091
• Nikkaji Number: J247.997D
• Wikipedia: Fotemustine
• Wikidata: Q1439555
• NCI Thesaurus Code: C1106
• ChEMBL ID: CHEMBL549386
• Mol file: 92118-27-9.mol

Synonyms:diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate;fotemustine;Muphoran;Mustoforan;S 10036;S-10036

Chemical Property of Fotemustine

Chemical Property:

• Melting Point: 85°
• Boiling Point: °Cat760mmHg
• PKA: 9.47±0.46(Predicted)
• Flash Point: °C
• PSA: 107.11000
• Density: 1.37 g/cm³
• LogP: 2.92120
• Storage Temp.: 2-8°C
• Solubility.: H2O: ≥1mg/mL
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 315.0750854
• Heavy Atom Count: 19
• Complexity: 334

Purity/Quality:

98% min ^*data from raw suppliers

Fotemustine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
• Recent ClinicalTrials: Fotemustine and Dacarbazine Versus Dacarbazine +/- Alpha Interferon in Advanced Malignant Melanoma
• Recent EU Clinical Trials: A PHASE III MULTICENTER, RANDOMIZED STUDY COMPARING CONSOLIDATION WITH (90)YTTRIUM-LABELED IBRITUMOMAB TIUXETAN (ZEVALIN?) RADIOIMMUNOTHERAPY VS AUTOLOGOUS STEM CELL TRANSPLANTATION (ASCT) IN PATIENTS WITH RELAPSED FOLLICULAR LYMPHOMA (FL) AGED 18-65 YEARS
• Description: Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.
• Uses: Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.

Technology Process of Fotemustine

There total 1 articles about Fotemustine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

→ fotemustine (92118-27-9)

Guidance literature:

Refernces