3-Amino-4-methoxybenzenesulfonamide

Base Information

• Chemical Name: 3-Amino-4-methoxybenzenesulfonamide
• CAS No.: 6973-08-6
• Molecular Formula: C7H10N2O3S
• Molecular Weight: 202.234
• Hs Code.: 2935009090
• European Community (EC) Number: 230-215-7
• NSC Number: 36970
• DSSTox Substance ID: DTXSID1064530
• Nikkaji Number: J30.810B
• Wikidata: Q81991628
• Mol file: 6973-08-6.mol

Synonyms:3-Amino-4-methoxybenzenesulfonamide;6973-08-6;Benzenesulfonamide, 3-amino-4-methoxy-;3-amino-4-methoxybenzene-1-sulfonamide;Metanilamide, 4-methoxy-;3-Amino-4-methoxybenzenesulphonamide;NSC36970;SCHEMBL1806001;DTXSID1064530;EINECS 230-215-7;3-amino-4-methoxy-benzenesulfonamide;GS1135;MFCD04035414;NSC 36970;NSC-36970;AKOS002548022;AT23168;CS-0241847;FT-0723125;EN300-23923;Z166648618

Chemical Property of 3-Amino-4-methoxybenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.39E-07mmHg at 25°C
• Melting Point: 142-142.5 °C
• Boiling Point: 429.5°C at 760 mmHg
• PKA: 10.52±0.60(Predicted)
• Flash Point: 213.6°C
• PSA: 103.79000
• Density: 1.397g/cm³
• LogP: 2.28710
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 202.04121336
• Heavy Atom Count: 13
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-4-methoxybenzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)S(=O)(=O)N)N

Technology Process of 3-Amino-4-methoxybenzenesulfonamide

There total 7 articles about 3-Amino-4-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-methoxybenzene sulfonamide (1129-26-6) → 1-methoxy-2-amino-benzene-4-sulfonamide (6973-08-6)

Guidance literature:

With ferrous(II) sulfate heptahydrate; hydroxylamine triflate; at 60 ℃; for 2h;

DOI:10.1039/C8SC04966A

Reference yield:

3-Amino-4-methoxy benzene sulphonylfluoride (498-74-8) → 1-methoxy-2-amino-benzene-4-sulfonamide (6973-08-6)

Guidance literature:

With ammonium hydroxide; In water; at 0 - 50 ℃;

Reference yield:

3-acetylamino-4-methoxy-benzenesulfonic acid amide (85605-29-4) → 1-methoxy-2-amino-benzene-4-sulfonamide (6973-08-6)

Guidance literature:

With sulfuric acid;

upstream raw materials:

3-acetylamino-4-methoxy-benzenesulfonic acid amide

2-methoxyacetanilide

3-(acetylamino)-4-methoxybenzensulfonyl chloride

3-Amino-4-methoxy benzene sulphonylfluoride

Downstream raw materials:

3-[[4-[N-(2,3-dimethyl-2H-indazol-6-yl)-N-methylamino]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl]amino]-4-methoxy-benzenesulfonamide

3-Isothiocyanato-4-methoxy-benzenesulfonamide

4-methoxy-3-thioureido-benzenesulfonamide

4-methoxy-3-({4-[(3-methyl-1H-indazol-6-yl)amino]-2-pyrimidinyl}amino)benzenesulfonamide

Refernces

• 1、 -. "FUSED HETEROARYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION". Page/Page column 31. . Retrieved 2012/06/01.
• 2、 -. "BISTHIAZOLE INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION". Page/Page column 58. . Retrieved 2012/06/01.