4-hydroxytriazolam

Base Information

• Chemical Name: 4-hydroxytriazolam
• CAS No.: 65686-11-5
• Molecular Formula: C17H12Cl2N4O
• Molecular Weight: 359.214
• Mol file: 65686-11-5.mol

Synonyms:8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol;

Chemical Property of 4-hydroxytriazolam

Chemical Property:

• Vapor Pressure: 1.62E-14mmHg at 25°C
• Melting Point: 280-282oC
• Boiling Point: 584.7°Cat760mmHg
• Flash Point: 307.4°C
• PSA: 63.30000
• Density: 1.54g/cm³
• LogP: 3.16000
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

4-HYDROXY TRIAZOLAM 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxytriazolam

There total 2 articles about 4-hydroxytriazolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triazolam (28911-01-5) → 4-Hydroxytriazolam (65686-11-5)

Guidance literature:

With human hepatocytes; Williams' Medium E cell culture medium; In acetonitrile; for 0.75h; pH=7.4; Enzyme kinetics;

DOI:10.1080/00498250701834665

Reference yield:

→ 4-Hydroxytriazolam (65686-11-5)

Guidance literature:

entspr.Benzodiazepin,K-O-tBu,O2;

DOI:10.1021/jm00210a022

upstream raw materials:

triazolam

Refernces

• 1、 Hallifax,Galetin,Houston. "Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines". . p. 353 - 367. Retrieved 2008/12/21.