Silane, dimethyl(1-methylethoxy)[3-methyl-2-methylene-4-(phenylmethoxy)butyl]- , (S)-

Base Information

• Chemical Name: Silane, dimethyl(1-methylethoxy)[3-methyl-2-methylene-4-(phenylmethoxy)butyl]- , (S)-
• CAS No.: 185410-44-0
• Molecular Formula: C₁₈H₃₀O₂Si
• Molecular Weight: 306.521
• Mol file: 185410-44-0.mol

Synonyms:

Chemical Property of Silane, dimethyl(1-methylethoxy)[3-methyl-2-methylene-4-(phenylmethoxy)butyl]- , (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Silane, dimethyl(1-methylethoxy)[3-methyl-2-methylene-4-(phenylmethoxy)butyl]- , (S)-

There total 1 articles about Silane, dimethyl(1-methylethoxy)[3-methyl-2-methylene-4-(phenylmethoxy)butyl]- , (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethylisopropoxydimethylsilane (18171-11-4) + methyl (S)-3-benzyloxy-2-methylpropanoate (74924-27-9) → ((S)-4-Benzyloxy-3-methyl-2-methylene-butyl)-isopropoxy-dimethyl-silane (185410-44-0)

Guidance literature:

With cerium(III) chloride; magnesium; ethylene dibromide; Multistep reaction; 1) THF, reflux, 1 h, 2) THF, -78 deg C -> room temperature; room temperature, 4 h;

DOI:10.1021/jo961639h

Reference yield:

((S)-4-Benzyloxy-3-methyl-2-methylene-butyl)-isopropoxy-dimethyl-silane (185410-44-0) → (S)-4-Benzyloxy-3-methyl-2-methylene-butan-1-ol

Guidance literature:

With potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; for 22h; Ambient temperature;

DOI:10.1021/jo961639h

Reference yield:

((S)-4-Benzyloxy-3-methyl-2-methylene-butyl)-isopropoxy-dimethyl-silane (185410-44-0) → (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-4-benzyloxy-3-methyl-2-methylene-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: KHCO₃, KF*2H₂O, aq. H₂O₂ / tetrahydrofuran; methanol / 22 h / Ambient temperature

2: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 0.17 h / Ambient temperature

With dmap; potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/jo961639h

upstream raw materials:

chloromethylisopropoxydimethylsilane

methyl (S)-3-benzyloxy-2-methylpropanoate

Refernces