cyclohex-2-en-1-ylacetic acid

Base Information

• Chemical Name: cyclohex-2-en-1-ylacetic acid
• CAS No.: 3675-31-8
• Molecular Formula: C8H12 O2
• Molecular Weight: 140.182
• Mol file: 3675-31-8.mol

Synonyms:(2-Cyclohexenyl)aceticacid; 2-Cyclohexeneacetic acid; NSC 18900

Chemical Property of cyclohex-2-en-1-ylacetic acid

Chemical Property:

• Vapor Pressure: 0.00312mmHg at 25°C
• Boiling Point: 262.9°Cat760mmHg
• Flash Point: 160.2°C
• Density: 1.062g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclohex-2-en-1-ylacetic acid

There total 23 articles about cyclohex-2-en-1-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (cyclohexen-3-yl)acetate (21331-58-8) → 2-(cyclohex-2-enyl)acetic acid (3675-31-8)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; Heating;

DOI:10.1016/S0040-4020(01)80306-9

Reference yield: 92.0%

C15H18Cl2O3Te (88850-07-1) → 2-(cyclohex-2-enyl)acetic acid (3675-31-8) + bis(4-methoxyphenyl)ditelluride (35684-37-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; for 0.166667h; Ambient temperature;

Reference yield: 78.0%

cyclohex-2-enyl-malonic acid (2138-99-0) → 2-(cyclohex-2-enyl)acetic acid (3675-31-8)

Guidance literature:

With dimethyl sulfoxide; at 120 ℃; for 4h;

DOI:10.1021/jacs.6b08932

upstream raw materials:

cyclohex-2-enyl-malonic acid

2-cyclohexenylacetaldehyde

ethyl (cyclohexen-3-yl)acetate

(1α,6α,7α)-bicyclo[4.1.0]heptane-7-carboxylic acid

Downstream raw materials:

6-chloro-3-cyclohex-2-enylmethyl-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

N-Methyl-2-(2-cyclohexen-1-yl)-acetamid

(3aα,7α,7aα)-hexahydro-7-(phenylseleno)-2(3H)-benzofuranone

(3aS,7aR)-7-Phenylselanyl-hexahydro-benzofuran-2-one

Refernces

• 1、 McCourt, Ruairi O.,Dénès, Fabrice,Sanchez-Sanz, Goar,Scanlan, Eoin M.. "Rapid Access to Thiolactone Derivatives through Radical-Mediated Acyl Thiol-Ene and Acyl Thiol-Yne Cyclization". supporting information. p. 2948 - 2951. Retrieved 2018/05/28.
• 2、 Shuler, Scott A.,Yin, Guoyin,Krause, Sarah B.,Vesper, Caroline M.,Watson, Donald A.. "Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction". supporting information. p. 13830 - 13833. Retrieved 2016/11/06.