1,1-hydroxyoctanodiphosphonate

Base Information

• Chemical Name: 1,1-hydroxyoctanodiphosphonate
• CAS No.: 53019-19-5
• Molecular Formula: C₈H₂₀O₇P₂
• Molecular Weight: 290.19
• Hs Code.: 2931900090
• Mol file: 53019-19-5.mol

Synonyms:Phosphonicacid, (1-hydroxyoctylidene)bis- (9CI); Phosphonic acid,(1-hydroxyoctylidene)di- (7CI); 1-Hydroxyoctane-1,1-diphosphonic acid;1-Hydroxyoctylidene-1,1-bisphosphonate; 1-Hydroxyoctylidenediphosphonic acid

Chemical Property of 1,1-hydroxyoctanodiphosphonate

Chemical Property:

• Vapor Pressure: 5.84E-14mmHg at 25°C
• Boiling Point: 541°Cat760mmHg
• Flash Point: 281°C
• PSA: 154.91000
• Density: 1.477g/cm³
• LogP: 1.34840
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(1-Hydroxyoctane-1,1-diyl)diphosphonic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-hydroxyoctanodiphosphonate

There total 2 articles about 1,1-hydroxyoctanodiphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Octanoic acid (124-07-2) → hydroxyoctane-1, 1-diphosphonic acid (53019-19-5)

Guidance literature:

Octanoic acid; With phosphonic Acid; benzenesulfonic acid; phosphorus trichloride; at 65 ℃; for 16h;

With water; at 100 ℃; for 5h;

DOI:10.1016/S0960-894X(01)00057-9

Reference yield:

n-octanoic acid chloride (111-64-8) + phosphorous acid (10294-56-1) → hydroxyoctane-1, 1-diphosphonic acid (53019-19-5)

Guidance literature:

With acetic anhydride;

upstream raw materials:

Octanoic acid

n-octanoic acid chloride

phosphorous acid

Refernces

• 1、 Roth, Anke G.,Drescher, Daniela,Reamer, Susanne,Arenz, Christoph,Yang, Yang,Uhlig, Stefan. "Potent and selective inhibition of acid sphingomyelinase by bisphosphonates". scheme or table. p. 7560 - 7563. Retrieved 2009/12/29.
• 2、 Szajnman, Sergio H.,Bailey, Brian N.,Docampo, Roberto,Rodriguez, Juan B.. "Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi". . p. 789 - 792. Retrieved 2007/10/03.