2,5-Dibromo-3-nitropyridine

Base Information

• Chemical Name: 2,5-Dibromo-3-nitropyridine
• CAS No.: 15862-37-0
• Molecular Formula: C5H2Br2N2O2
• Molecular Weight: 281.891
• Hs Code.: 2933399090
• European Community (EC) Number: 808-084-8
• NSC Number: 170627
• DSSTox Substance ID: DTXSID20305387
• Nikkaji Number: J1.453.077K
• Wikidata: Q72464705
• Mol file: 15862-37-0.mol

Synonyms:2,5-Dibromo-3-nitropyridine;15862-37-0;2,5-Dibromo-3-nitro-pyridine;MFCD09266223;NSC170627;PYRIDINE, 2,5-DIBROMO-3-NITRO-;SCHEMBL202290;DTXSID20305387;2,5-Di Bromo-3-Nitro Pyridine;BCP22083;BBL100791;STL554585;2 pound not5-dibromo-3-nitropyridine;AKOS005255313;CS-W003617;DS-0464;NSC 170627;NSC-170627;PB16150;SB10155;AC-23053;BP-11623;SY014308;2,5-Dibromo-3-nitro-pyridine, AldrichCPR;A3501;AM20070008;D4702;FT-0646933;EN300-108015;W-205823

Chemical Property of 2,5-Dibromo-3-nitropyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 0.00263mmHg at 25°C
• Melting Point: 92.0 to 96.0 °C
• Refractive Index: 1.649
• Boiling Point: 272.7 °C at 760 mmHg
• PKA: -5.60±0.20(Predicted)
• Flash Point: 118.7 °C
• PSA: 58.71000
• Density: 2.221 g/cm³
• LogP: 3.03800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 281.84625
• Heavy Atom Count: 11
• Complexity: 161

Purity/Quality:

98% ^*data from raw suppliers

2,5-Dibromo-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1[N+](=O)[O-])Br)Br
• Uses: 2,5-Dibromo-3-nitropyridine is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 2,5-Dibromo-3-nitropyridine

There total 6 articles about 2,5-Dibromo-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-3-nitro-1H-pyridin-2-one (15862-34-7) → 2,5-dibromo-3-nitro-pyridine (15862-37-0)

Guidance literature:

With pyridine; phosphorus(V) oxybromide; N,N-dimethyl-formamide; In toluene; at 90 ℃; for 15.5h;

Reference yield: 97.0%

5-bromo-3-nitro-2-pyridone (15862-34-7) → 2,5-dibromo-3-nitro-pyridine (15862-37-0)

Guidance literature:

With phosphorus(V) oxybromide; In N,N-dimethyl-formamide; toluene; at 90 ℃; for 16h;

Reference yield: 58.9%

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 2,5-dibromo-3-nitro-pyridine (15862-37-0)

Guidance literature:

5-bromo-3-nitro-pyridin-2-ylamine; With hydrogen bromide; In water; at 0 - 5 ℃;

With water; bromine; sodium sulfite; at 0 ℃; for 0.75h;

With sodium hydroxide; In water; at 20 ℃; for 1h;

upstream raw materials:

5-bromo-3-nitro-2-pyridone

5-bromo-3-nitro-pyridin-2-ylamine

5-bromo-2-pyridylamine

2-hydroxy-3-nitropyridine

Refernces

• 1、 -. "NEW BIARYL AMIDE DERIVATIVES". Page/Page column 53. . Retrieved 2012/07/14.
• 2、 O'Shea, Paul D.,Gauvreau, Danny,Gosselin, Francis,Hughes, Greg,Nadeau, Christian,Roy, Amelie,Shultz, C. Scott. "Practical synthesis of a potent bradykinin B1 antagonist via enantioselective hydrogenation of a pyridyl N-acyl enamide". supporting information; experimental part. p. 4547 - 4553. Retrieved 2009/09/30.