Technology Process of Silane,
(1,1-dimethylethyl)dimethyl[[(2S,6R,10S,14R)-2,6,10,14-tetramethyl-16
-(phenylmethoxy)-9-(phenylsulfonyl)hexadecyl]oxy]-
There total 22 articles about Silane,
(1,1-dimethylethyl)dimethyl[[(2S,6R,10S,14R)-2,6,10,14-tetramethyl-16
-(phenylmethoxy)-9-(phenylsulfonyl)hexadecyl]oxy]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium;
In
tetrahydrofuran; hexane;
1.) -78 deg C, 15 min; 0 deg C, 15 min, 2.) -25 deg C, 1 h;
DOI:10.1021/jo962327h
- Guidance literature:
-
Multi-step reaction with 12 steps
1: imidazole / dimethylformamide
2: DIBAH
3: TfOH / diethyl ether
4: aq. HCl / tetrahydrofuran
5: pyridine
6: K2CO3 / dimethylformamide
7: m-CPBA / CH2Cl2
8: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
9: 86 percent / Na(Hg) / methanol
10: H2 / 10percent Pd/C / ethyl acetate
11: I2, Ph3P, imidazole / benzene
12: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
With
pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; hydrogen; iodine; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39940000137
- Guidance literature:
-
Multi-step reaction with 13 steps
1: aq. HCl / tetrahydrofuran
2: imidazole / dimethylformamide
3: DIBAH
4: TfOH / diethyl ether
5: aq. HCl / tetrahydrofuran
6: pyridine
7: K2CO3 / dimethylformamide
8: m-CPBA / CH2Cl2
9: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
10: 86 percent / Na(Hg) / methanol
11: H2 / 10percent Pd/C / ethyl acetate
12: I2, Ph3P, imidazole / benzene
13: 1.) BuLi, HMPA / 1.) THF, -78 deg C, 2.) THF, from -25 deg C to RT
With
pyridine; 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; sodium amalgam; trifluorormethanesulfonic acid; hydrogen; iodine; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39940000137