3-PHENYL-CYCLOBUTAN-1-ONE

Base Information

• Chemical Name: 3-PHENYL-CYCLOBUTAN-1-ONE
• CAS No.: 52784-31-3
• Molecular Formula: C10H10O
• Molecular Weight: 146.1858
• Hs Code.: 2914399090
• Mol file: 52784-31-3.mol

Synonyms:3-phenylcyclobutan-1-one;

Chemical Property of 3-PHENYL-CYCLOBUTAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.0141mmHg at 25°C
• Refractive Index: 1.544
• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 105.8 °C
• PSA: 17.07000
• Density: 1.11 g/cm³
• LogP: 2.13310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Phenylcyclobutanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-PHENYL-CYCLOBUTAN-1-ONE

There total 33 articles about 3-PHENYL-CYCLOBUTAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-3-phenylcyclobut-2-enone (91391-31-0) → 3-Phenylcyclobutanone (52784-31-3)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In methanol;

DOI:10.1021/ja00076a024

Reference yield: 86.0%

2,2-dichloro-3-phenylcyclobutanone (13866-28-9) → 3-Phenylcyclobutanone (52784-31-3)

Guidance literature:

With acetic acid; zinc; for 5h; Heating;

DOI:10.1021/jo800246g

Reference yield: 82.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 3-Phenylcyclobutanone (52784-31-3)

Guidance literature:

N,N-dimethyl acetamide; With trifluoromethylsulfonic anhydride; In 1,2-dichloro-ethane; at 5 ℃; for 0.5h;

styrene; In 1,2-dichloro-ethane; for 18h; Reflux;

DOI:10.1002/ejoc.201500746

upstream raw materials:

4,4-dichloro-3-phenyl-2-cyclobuten-1-one

diazomethane

phenylacetic acid

styrene

Downstream raw materials:

3-phenylcyclopentanone

(E)-benzalacetone

4,5-dihydro-5-phenyl-2(3H)-furanone

1,3-diphenylbutane-1-one

Refernces

• 1、 Ban, Kazuho,Miki, Yuya,Sajiki, Hironao,Sawama, Yoshinari,Tomita, Naohito. "Synthesis of 1-Pyrroline by Denitrogenative Ring Expansion of Cyclobutyl Azides under Thermal Conditions". supporting information. p. 3481 - 3484. Retrieved 2021/06/17.
• 2、 Dong, Bingbing,Lu, Jiansha,Bao, Honghao,Zhang, Yuanyuan,Liu, Yingguo,Leng, Yuting. "Copper-Catalyzed Sulfonylation of Cyclobutanone Oxime Esters with Sulfonyl Hydrazides". supporting information. p. 3769 - 3776. Retrieved 2021/07/14.