4-(Phenylthio)-1,2-naphthalenedione

Base Information

• Chemical Name: 4-(Phenylthio)-1,2-naphthalenedione
• CAS No.: 18916-59-1
• Molecular Formula: C16H10O2S
• Molecular Weight: 266.31400
• Mol file: 18916-59-1.mol

Synonyms:4-Phenylmercapto-naphthochinon-(1,2);4-(phenylthio)naphthalen-1,2-dione;4-Phenylsulfanyl-[1,2]naphthoquinone;4-(phenylthio)-1,2-naphthoquinone;4-phenylthionaphthalene-1,2-dione;

Chemical Property of 4-(Phenylthio)-1,2-naphthalenedione

Chemical Property:

• Melting Point: 168 - 170 °C
• PSA: 59.44000
• LogP: 3.58520

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(Phenylthio)-1,2-naphthalenedione

There total 7 articles about 4-(Phenylthio)-1,2-naphthalenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

thiophenol (108-98-5) + 1,2-naphthoquinone (524-42-5) → 4-(phenylthio)naphthalene-1,2 dione (18916-59-1)

Guidance literature:

In methanol; at 20 ℃; for 8h;

DOI:10.1039/c0ce00591f

Reference yield: 30.0%

sodium 1,2-naphthoquinone-4-sulfonate (521-24-4) + thiophenol (108-98-5) → 4-(phenylthio)naphthalene-1,2 dione (18916-59-1)

Guidance literature:

In ethanol; water; at 25 ℃; for 0.666667h; Sonication;

DOI:10.1039/d0md00072h

Reference yield:

thiophenol (108-98-5) + 1,2-naphthoquinone (524-42-5) → C16H12O2S + 4-(phenylthio)naphthalene-1,2 dione (18916-59-1)

Guidance literature:

With air; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/acs.joc.6b01105

upstream raw materials:

4-(phenylthio)naphthalen-1-ol

α-naphthol

thiophenol

1,2-naphthoquinone

Downstream raw materials:

5-phenylthiobenzo[a]phenazine

Refernces

• 1、 Almeida, Renata G.,Barbosa, Juliana M. C.,De Carvalho, Guilherme G. C.,De Castro, Solange L.,De Simone, Carlos A.,Goulart, Marilia O. F.,Kharma, Ammar,Paier, Carlos R. K.,Pessoa, Claudia,Pinheiro, Daniel P.,Da Silva Júnior, Eufranio N.,Rosa, Luísa G.,Valen?a, Wagner O.. "Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: Redox and biological implications". . p. 1145 - 1160. Retrieved 2020/11/03.