Eprinex

Base Information

• Chemical Name: Eprinex
• CAS No.: 123997-26-2
• Deprecated CAS: 159628-36-1
• Molecular Formula: C50H75NO14;C49H73NO14
• Molecular Weight: (914.14);(900.12)
• Hs Code.: 2941906000
• Wikidata: Q72471014
• NCI Thesaurus Code: C83694
• Metabolomics Workbench ID: 152609
• Mol file: 123997-26-2.mol

Synonyms:4''-epi-methylamino-4''-deoxyavermectin B1;4''-epiacetylamino-4''-deoxyavermectin B1;4''-epiacetylamino-4''-deoxyavermectin B1, (4''R)-isomer;avermectin B1, 4''-(acetylamino)-4''-deoxy-, (4''R)-;emamectin;GWN-1972;MK 243;MK-243

Chemical Property of Eprinex

Chemical Property:

• Appearance/Colour: White or light yellow crystalline powder
• Melting Point: 163-166 °C
• Refractive Index: 1.567
• Flash Point: 2 °C
• PSA: 178.93000
• Density: 1.23 g/cm³
• LogP: 5.46970
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 8
• Exact Mass: 899.50310600
• Heavy Atom Count: 64
• Complexity: 1830

Purity/Quality:

99% ^*data from raw suppliers

Eprinomectin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,F
• Hazard Codes: F,Xn,N,T
• Statements: 11-20/21/22-36-62-50/53-25-63
• Safety Statements: 26-36/37-16-61-60-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1C=CC=C2COC3C2(C(C=C(C3O)C)C(=O)OC4CC(CC=C(C1OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)NC(=O)C)OC)OC)C)OC7(C4)C=CC(C(O7)C(C)C)C)O
• Isomeric SMILES: C[C@H]1/C=C\C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(\[C@H]1O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O[C@H]6C[C@H]([C@@H]([C@@H](O6)C)NC(=O)C)OC)OC)/C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C(C)C)C)O
• Description: Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma. Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is comprised of eprinomectin B1a and eprinomectin B1b . Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg. Formulations containing eprinomectin have been used in the treatment and control of a variety of endo- and ectoparasites in cattle.
• Uses: A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect. A mixture of Eprinomectin B1a and B1b showing anti-anthelintic activity