1-CYANO-6-METHOXYNAPHTHALENE

Base Information

• Chemical Name: 1-CYANO-6-METHOXYNAPHTHALENE
• CAS No.: 77029-01-7
• Molecular Formula: C12H9NO
• Molecular Weight: 183.21
• Hs Code.: 2926909090
• Mol file: 77029-01-7.mol

Synonyms:1-Naphthonitrile,6-methoxy- (4CI);5-Cyano-2-methoxynaphthalene;6-Methoxy-1-cyanonaphthalene;6-Methoxy-1-naphthalenecarbonitrile;

Chemical Property of 1-CYANO-6-METHOXYNAPHTHALENE

Chemical Property:

• Vapor Pressure: 5.11E-05mmHg at 25°C
• Melting Point: 79 °C
• Refractive Index: 1.622
• Boiling Point: 348.2 °C at 760 mmHg
• Flash Point: 146.9 °C
• PSA: 33.02000
• Density: 1.16 g/cm³
• LogP: 2.72008

Purity/Quality:

99% ^*data from raw suppliers

1-Cyano-6-methoxynaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Cyano-6-methoxynaphthalene is used as a reactant in the preparation of ferrocenyl selenazoles and diferrocenylselenadiazole as antibacterial agents.

Technology Process of 1-CYANO-6-METHOXYNAPHTHALENE

There total 7 articles about 1-CYANO-6-METHOXYNAPHTHALENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-methoxy-3,4-dihydronaphthalene-1-carbonitrile (6398-50-1) → 6-methoxy-[1]naphthonitrile (77029-01-7)

Guidance literature:

With 2,3-dihydro-5,6-dicyano-p-benzoquinone; In benzene; for 2h; Heating;

DOI:10.1021/jo00324a039

Reference yield: 78.0%

trimethylsilyl cyanide (7677-24-9) + 6-methoxy-1,2,3,4-tetrahydronaphthalene (1730-48-9) → 6-methoxy-[1]naphthonitrile (77029-01-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 60 ℃; for 24h; DDQ/substrate ratio = 3;

DOI:10.1246/cl.1988.1581

Reference yield:

6-methoxy-3,4-dihydro-1(2H)-naphthalenone (1078-19-9) → 6-methoxy-[1]naphthonitrile (77029-01-7)

Guidance literature:

palladium-carbon; In nitrobenzene;

upstream raw materials:

6-methoxynaphthylamine

potassium cyanide

trimethylsilyl cyanide

6-methoxy-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

6-hydroxy-1-naphthoic acid

2-(6-methoxy-1-naphthyl)-1-phenyl-2-propanol

1-(6-methoxynaphthalen-1-yl)ethanone

(E)-N-methyl-N-(3-phenyl-2-propenyl)-6-methoxy-1-naphthalenemethanamine

Refernces

• 1、 Tolbert, Laren M.,Haubrich, Jeanne E.. "Photoexcited proton transfer from enhanced photoacids". . p. 10593 - 10600. Retrieved 2007/10/02.
• 2、 Lemaire, Marc,Doussot, Joel,Guy, Alain. "Benzylic Cyanation via Oxidation and Simultaneous Nucleophilic Substitution". . p. 1581 - 1584. Retrieved 2007/10/02.