Technology Process of (1E)-2,2,3,3,3-Pentafluoro-N-(4-methoxyphenyl)propan-1-imine
There total 1 articles about (1E)-2,2,3,3,3-Pentafluoro-N-(4-methoxyphenyl)propan-1-imine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
for 1.5h;
Reflux;
Inert atmosphere;
Dean-Stark;
DOI:10.1021/acs.joc.8b01743
- Guidance literature:
-
With
tetrakis(acetonitrile)copper(I)tetrafluoroborate; C25H25FeOP; triethylamine;
In
diethyl ether;
at -20 ℃;
enantioselective reaction;
Inert atmosphere;
DOI:10.1039/c3cc43025a
DOI:10.1039/c3cc43025a
- Guidance literature:
-
C10H8F5NO;
With
(2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine;
In
1-methyl-pyrrolidin-2-one;
at 20 ℃;
for 0.25h;
Inert atmosphere;
propionaldehyde;
In
1-methyl-pyrrolidin-2-one;
at -20 - 0 ℃;
for 72h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
methanol;
at 0 ℃;
for 3h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/ejoc.200900509