N-Octyltrifluoroacetamide

Base Information

• Chemical Name: N-Octyltrifluoroacetamide
• CAS No.: 1894-03-7
• Molecular Formula: C10H18F3NO
• Molecular Weight: 225.254
• Hs Code.: 2924199090
• Mol file: 1894-03-7.mol

Synonyms:N-Octyl-trifluoracetamid;N-n-Octyltrifluoroacetamide;Octane,1-amino,trifluoroacetyl;N-Octyltrifluoroacetamide;2,2,2-trifluoro-N-octyl-acetamide;

Chemical Property of N-Octyltrifluoroacetamide

Chemical Property:

• PSA: 32.59000
• LogP: 3.86570

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Octyltrifluoroacetamide

There total 10 articles about N-Octyltrifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-bromo-octane (111-83-1) + 2,2,2-trifluoroacetamide (354-38-1) → octanol (111-87-5) + 2,2,2-trifluoro-N-octylacetamide (1894-03-7)

Guidance literature:

With potassium carbonate; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield: 78.0%

n-octyl methanesulfonate (16156-52-8) + 2,2,2-trifluoroacetamide (354-38-1) → octanol (111-87-5) + 2,2,2-trifluoro-N-octylacetamide (1894-03-7)

Guidance literature:

With potassium carbonate; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 50 ℃; for 24h;

Reference yield: 65.0%

n-chlorooctane (111-85-3) → oct-1-ene (111-66-0,25068-25-1) + 2,2,2-trifluoro-N-octylacetamide (1894-03-7)

Guidance literature:

With 2,2,2-trifluoroacetamide; sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Yields of byproduct given;

DOI:10.1055/s-1984-31028

upstream raw materials:

n-octyl methanesulfonate

2,2,2-trifluoroacetamide

n-chlorooctane

1-Iodooctane

Downstream raw materials:

n-Octylamine

n-dioctylamine

oct-1-ene

N,N-Dioctyl-trifluoracetamid

Refernces

• 1、 Harland, Philip A.,Hodge, Philip,Maughan, Wilfrid,Wildsmith, Eric. "Synthesis of Primary Amines via Alkylation of the Sodium Salt of Trifluoroacetamide: An Alternative to the Gabriel Synthesis". . p. 941 - 943. Retrieved 2007/10/02.