4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID

Base Information

• Chemical Name: 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID
• CAS No.: 5496-35-5
• Molecular Formula: C22H16N2O2
• Molecular Weight: 340.381
• Hs Code.: 2933290090
• Mol file: 5496-35-5.mol

Synonyms:2(p-Carboxyphenyl)-4,5-diphenylimidazole;Benzoic acid, 4-(4,5-diphenyl-1H-imidazol-2-yl)-;4-(4,5-diphenyl-1H-imidazol-2-yl)benzoic acid;

Chemical Property of 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 4.3E-15mmHg at 25°C
• Refractive Index: 1.66
• Boiling Point: 596.9 °C at 760 mmHg
• PKA: 3.31±0.10(Predicted)
• Flash Point: 314.8 °C
• PSA: 65.98000
• Density: 1.263 g/cm³
• LogP: 5.10890
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4,5-Diphenyl-1H-imidazol-2-yl)benzoic Acid is an anti-malarial agent with displayed ability to inhibit the activity of three metalloaminopeptidases. In addition, inhibits early stage of HIV-1 replication through disruption of the capsid protein.

Technology Process of 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID

There total 2 articles about 4-(4,5-DIPHENYL-1H-IMIDAZOL-2-YL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Carboxybenzaldehyde (619-66-9) + benzil (134-81-6) → 4?((4,5?diphenyl)?1H?imidazol?2?yl)benzoic acid (5496-35-5)

Guidance literature:

With copper(II) ferrite; ammonium acetate; In neat (no solvent); at 90 ℃; for 0.4h; Green chemistry;

DOI:10.1080/15533174.2016.1212223

Reference yield: 95.0%

terephthalaldehyde, (623-27-8) + benzil (134-81-6) → 4?((4,5?diphenyl)?1H?imidazol?2?yl)benzoic acid (5496-35-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; ammonium acetate; acetic acid; at 105 ℃; for 6h;

Reference yield: 85.0%

allyl bromide (106-95-6) + 4?((4,5?diphenyl)?1H?imidazol?2?yl)benzoic acid (5496-35-5) → C28H24N2O2

Guidance literature:

4?((4,5?diphenyl)?1H?imidazol?2?yl)benzoic acid; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

allyl bromide; In dimethyl sulfoxide;

DOI:10.1002/jhet.3215

upstream raw materials:

4-Carboxybenzaldehyde

benzil

terephthalaldehyde,

Refernces

• 1、 -. "IMIDAZOLE COMPOUND". Paragraph 0140-0142. . Retrieved 2021/02/09.
• 2、 -. "Fluorescent compound, preparation method and application thereof". Paragraph 0036; 00037; 0038; 0039; 0040; 0041. . Retrieved 2020/09/16.