2,2,2-Trifluoroethylhydrazine

Base Information

• Chemical Name: 2,2,2-Trifluoroethylhydrazine
• CAS No.: 5042-30-8
• Molecular Formula: C2H5F3N2
• Molecular Weight: 114.07
• Hs Code.: 29280000
• European Community (EC) Number: 225-734-0
• NSC Number: 111156
• DSSTox Substance ID: DTXSID10198462
• Nikkaji Number: J203.266J
• Wikidata: Q72511121
• Mol file: 5042-30-8.mol

Synonyms:(2,2,2-Trifluoroethyl)hydrazine;1-(2,2,2-Trifluoroethyl)hydrazine;Hydrazine,(2,2,2-trifluoroethyl)-;Trifluoroethylhydrazine;

Chemical Property of 2,2,2-Trifluoroethylhydrazine

Chemical Property:

• Appearance/Colour: clear yellow to green liquid
• Vapor Pressure: 76.5mmHg at 25°C
• Refractive Index: n20/D 1.361
• Boiling Point: 83.1 ºC at 760 mmHg
• PKA: 5.38±0.10(Predicted)
• Flash Point: 42.8 ºC
• PSA: 38.05000
• Density: 1.261 g/cm³
• LogP: 1.10320
• Storage Temp.: Flammables area
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 114.04048265
• Heavy Atom Count: 7
• Complexity: 49.4

Purity/Quality:

99% ^*data from raw suppliers

1-Hydrazino-2,2,2-trifluoroethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-20/21/22
• Safety Statements: 36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(F)(F)F)NN
• Uses: 2,2,2-trifluoroethylhydrazine was added to myoglobin to study its interaction with heme protein. It was also used to determine aldehydes and acetone simultaneously in water.

Technology Process of 2,2,2-Trifluoroethylhydrazine

There total 1 articles about 2,2,2-Trifluoroethylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-(2,2,2-trifluoroethyl)hydrazinecarboxylate → 2,2,2,trifluoroethylhydrazine (5042-30-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2019.01.027

Reference yield: 99.0%

2,2,2,trifluoroethylhydrazine (5042-30-8) + N-(4-bromobenzylidene)glycine methyl ester (139575-14-7,120672-87-9) → 5-p-bromophenyl-6-trifluoromethyl-1,2,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid methyl ester

Guidance literature:

N-(4-bromobenzylidene)glycine methyl ester; With silver(I) acetate; caesium carbonate; In acetonitrile; at 20 ℃; for 0.05h; Schlenk technique;

2,2,2,trifluoroethylhydrazine; In acetonitrile; at 20 ℃; for 48h; Schlenk technique;

Reference yield: 97.0%

2,2,2,trifluoroethylhydrazine (5042-30-8) + methyl N-(4-chlorobenzylidene)glycinate (76862-09-4) → 5-(4-chlorophenyl)-6-trifluoromethyl-1,2,5,6-tetrahydro-1,2,4-triazin-3-carboxylic acid methyl ester

Guidance literature:

methyl N-(4-chlorobenzylidene)glycinate; With silver(I) acetate; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 0.05h; Schlenk technique;

2,2,2,trifluoroethylhydrazine; In tetrahydrofuran; at 20 ℃; for 36h; Schlenk technique;

Downstream raw materials:

7-((Z)-4-methyl-benzylidene)-3-p-tolyl-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide

7-((Z)-4-methyl-benzylidene)-3-p-tolyl-1-(2,2,2-trifluoro-ethyl)-1,4,6,7-tetrahydro-thiopyrano[4,3-c]pyrazole 5,5-dioxide

4-[6-(2-Chloro-4-methoxy-phenoxy)-hexyl]-3,5-diethyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazole

ethyl 4-<(2'-cyanobiphenyl-4-yl)methyl>-3-n-propyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate

Refernces