HISPOLON MONOMETHYL ETHER(P)

Base Information

• Chemical Name: HISPOLON MONOMETHYL ETHER(P)
• CAS No.: 1924-25-0
• Molecular Formula: C13H14O4
• Molecular Weight: 234.252
• Mol file: 1924-25-0.mol

Synonyms:HISPOLON MONOMETHYL ETHER(P);.Feruloylaceton;(E)-6-(4-hydroxy-3-methoxyphenyl)hex-5-ene-2,4-dione;.feruloylacetone;.6-(4-hydroxy-3-methoxyphenyl)hex-5E-ene-2,4-dione;.1-(4'-hydroxy-3'-methoxyphenyl)-1-hexene-3,5-dione;.6-(4-Hydroxy-3-methoxyphenyl)hex-5-ene-2,4-dione;

Chemical Property of HISPOLON MONOMETHYL ETHER(P)

Chemical Property:

• PSA: 63.60000
• LogP: 1.96220

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HISPOLON MONOMETHYL ETHER(P)

There total 7 articles about HISPOLON MONOMETHYL ETHER(P) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

vanillin (121-33-5,8014-42-4) + acetylacetone (123-54-6,81235-32-7) → 4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)3,5-hexadien-2-one (1924-25-0)

Guidance literature:

acetylacetone; With boron trioxide; In ethyl acetate; at 85 ℃; for 1h;

vanillin; With boric acid tributyl ester; N-butylamine; In ethyl acetate; at 50 ℃; for 2h;

Reference yield: 37.0%

vanillin (121-33-5,8014-42-4) + acetylacetone (123-54-6,81235-32-7) → (5E)-6-(4-hydroxy-3-methoxyphenyl)hex-5-ene-2,4-dione (1924-25-0)

Guidance literature:

With boron trioxide; boric acid tributyl ester; N-butylamine; In ethyl acetate;

DOI:10.1016/S0022-2860(03)00050-4

Reference yield: 22.0%

vanillin (121-33-5,8014-42-4) + acetylacetone (123-54-6,81235-32-7) → curcumin (458-37-7) + 4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)3,5-hexadien-2-one (1924-25-0)

Guidance literature:

With piperidine; triethyl borate; boron trioxide; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2013.11.039

upstream raw materials:

vanillin

acetylacetone

curcumin

Downstream raw materials:

6-(p-hydroxy-m-methoxyphenyl)hexane-2,4-dione

Refernces

• 1、 Yang, Haixia,Sukamtoh, Elvira,Du, Zheyuan,Wang, Weicang,Ando, Manami,Kwakwa, Yaa Nyamekye,Zhang, Jianan,Zhang, Guodong. "Click chemistry approach to characterize curcumin-protein interactions in vitro and in vivo". . p. 1 - 6. Retrieved 2019.
• 2、 -. "Mitochondrial-targeting curcumin derivative as well as preparation method and medical application thereof". Paragraph 0074-0076; 0078; 0081-0084; 0085-0088; 0104; .... . Retrieved 2021/07/21.