Phosphinic amide, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-P,P-diphenyl-

Base Information

• Chemical Name: Phosphinic amide, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-P,P-diphenyl-
• CAS No.: 192461-85-1
• Molecular Formula: C21H20NOP
• Molecular Weight: 333.37
• Mol file: 192461-85-1.mol

Synonyms:

Chemical Property of Phosphinic amide, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-P,P-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphinic amide, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-P,P-diphenyl-

There total 9 articles about Phosphinic amide, N-[(1S)-2,3-dihydro-1H-inden-1-yl]-P,P-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[(1E)-2,3-dihydro-1H-inden-1-ylidene]-P,P-diphenylphosphinic amide (192461-80-6) → (S)-(-)-N-(1-indanamine)diphenylphosphinamide (192461-85-1)

Guidance literature:

With polymethylhydrosiloxane; diethylzinc; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine; In tetrahydrofuran; methanol; at 20 ℃; for 12h;

DOI:10.1002/adsc.200606149

Reference yield: 80.0%

C21H18NOP (154051-02-2) → (R)-N-(1-indanyl)-P,P-diphenylphosphinic amide + (S)-(-)-N-(1-indanamine)diphenylphosphinamide (192461-85-1)

Guidance literature:

With diphenylsilane; diethylzinc; (1R,2R)-N,N'-dibenzylcyclohexane-1,2-diamine; In methanol; hexane; toluene; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c1ob05074e

Reference yield:

N-[(1E)-2,3-dihydro-1H-inden-1-ylidene]-P,P-diphenylphosphinic amide (192461-80-6) → (R)-N-(1-indanyl)-P,P-diphenylphosphinic amide + (S)-(-)-N-(1-indanamine)diphenylphosphinamide (192461-85-1)

Guidance literature:

With sodium tetrahydroborate; (S,S)-Co(II) complex catalyst (C₄₆H₅₀N₂O₄Co); In ethanol; chloroform; at 0 ℃; for 4h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/cl.1997.493

upstream raw materials:

N-[(1E)-2,3-dihydro-1H-inden-1-ylidene]-P,P-diphenylphosphinic amide

C₂₁H₁₈NOP

indan-1-one oxime

chloro-diphenylphosphine

Downstream raw materials:

(S)-1-Aminoindane

Refernces

• 1、 Bez?ada, Agata,Szewczyk, Marcin,Mlynarski, Jacek. "Enantioselective Hydrosilylation of Imines Catalyzed by Chiral Zinc Acetate Complexes". . p. 336 - 342. Retrieved 2016/01/15.
• 2、 Kokura, Ai,Tanaka, Saiko,Teraoka, Haruna,Shibahrara, Atsushi,Ikeno, Taketo,Nagata, Takushi,Yamada, Tohru. "Chloroform is not solvent but activator for cobalt complex catalyst of enantioselective borohydride reduction". . p. 26 - 27. Retrieved 2007/10/03.