1,2,3,4-tetrahydro-N-(4-methylphenyl)-1-Naphthalenamine

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-N-(4-methylphenyl)-1-Naphthalenamine
• CAS No.: 192461-90-8
• Molecular Formula: C₁₇H₁₉N
• Molecular Weight: 237.345
• Mol file: 192461-90-8.mol

Synonyms:(rac)-N-p-tolyl-1,2,3,4-tetrahydronaphthalen-1-amine;1-Naphthalenamine,1,2,3,4-tetrahydro-N-(4-methylphenyl);

Chemical Property of 1,2,3,4-tetrahydro-N-(4-methylphenyl)-1-Naphthalenamine

Chemical Property:

• PSA: 12.03000
• LogP: 4.55750

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(p-tolyl)-1,2,3,4-Tetrahydronaphthalen-1-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-tetrahydro-N-(4-methylphenyl)-1-Naphthalenamine

There total 6 articles about 1,2,3,4-tetrahydro-N-(4-methylphenyl)-1-Naphthalenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

α-naphthol (90-15-3) + p-toluidine (106-49-0,12221-03-3) → (rac)-N-p-tolyl-1,2,3,4-tetrahydronaphthalen-1-amine (192461-90-8,1269472-37-8)

Guidance literature:

With Pd/C; sodium formate; In toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5sc00941c

Reference yield: 42.0%

1,2,3,4-tetrahydronaphthalen-1-amine (2217-40-5) + p-cresol (106-44-5) → (rac)-N-p-tolyl-1,2,3,4-tetrahydronaphthalen-1-amine (192461-90-8,1269472-37-8)

Guidance literature:

With [(η⁵-C₅(CH₃)₄^{3,5-bis(trifluoromethyl)benzene})RhCl₂]₂; sodium carbonate; In n-heptane; at 140 ℃; for 36h; Sealed tube; Inert atmosphere; Molecular sieve;

DOI:10.1021/jacs.1c12622

Reference yield:

tetralin (119-64-2) + p-toluidine (106-49-0,12221-03-3) → (rac)-N-p-tolyl-1,2,3,4-tetrahydronaphthalen-1-amine (192461-90-8,1269472-37-8)

Guidance literature:

With di-tert-butyl peroxide; In neat (no solvent); at 105 ℃; for 18h;

DOI:10.1021/acscatal.9b00259

upstream raw materials:

N-(p-tolyl)naphthalen-1-amine

1-Bromonaphthalene

p-toluidine

α-naphthol

Refernces

• 1、 Feng, Xuanyu,Ji, Pengfei,Li, Zhe,Drake, Tasha,Oliveres, Pau,Chen, Emily Y.,Song, Yang,Wang, Cheng,Lin, Wenbin. "Aluminum Hydroxide Secondary Building Units in a Metal-Organic Framework Support Earth-Abundant Metal Catalysts for Broad-Scope Organic Transformations". . p. 3327 - 3337. Retrieved 2019/03/26.
• 2、 Chen, Zhengwang,Zeng, Huiying,Gong, Hang,Wang, Haining,Li, Chao-Jun. "Palladium-catalyzed reductive coupling of phenols with anilines and amines: efficient conversion of phenolic lignin model monomers and analogues to cyclohexylamines". . p. 4174 - 4178. Retrieved 2015/06/25.