3,5-Dimethyl-2,6-diphenylpiperidin-4-one

Base Information

• Chemical Name: 3,5-Dimethyl-2,6-diphenylpiperidin-4-one
• CAS No.: 5707-11-9
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.382
• Mol file: 5707-11-9.mol

Synonyms:4-Piperidone,3,5-dimethyl-2,6-diphenyl- (6CI,7CI,8CI);3,5-Dimethyl-2,6-diphenyl-4-piperidinone; 3,5-Dimethyl-2,6-diphenyl-4-piperidone;NSC 319693

Chemical Property of 3,5-Dimethyl-2,6-diphenylpiperidin-4-one

Chemical Property:

• Vapor Pressure: 1.96E-07mmHg at 25°C
• Boiling Point: 425.1°Cat760mmHg
• Flash Point: 146°C
• PSA: 29.10000
• Density: 1.045g/cm³
• LogP: 4.24230

Purity/Quality:

99%min ^*data from raw suppliers

3,5-DIMETHYL-2,6-DIPHENYL-4-PIPERIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Dimethyl-2,6-diphenylpiperidin-4-one

There total 18 articles about 3,5-Dimethyl-2,6-diphenylpiperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzaldehyde (100-52-7) + pentan-3-one (96-22-0) → 3,5-dimethyl-2,6-diphenylpiperidin-4-one (5707-11-9,18699-96-2,37418-41-0,149116-46-1)

Guidance literature:

With ammonium acetate; In ethanol; at 70 ℃; for 1.5h;

DOI:10.1016/j.jorganchem.2019.04.004

Reference yield: 84.0%

t-3,t-5-Dimethyl-N-nitroso-r-2,c-6-diphenylpiperidin-4-one (102081-34-5) → 3,5-dimethyl-2,6-diphenylpiperidin-4-one (5707-11-9,18699-96-2,37418-41-0,149116-46-1)

Guidance literature:

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; In tetrahydrofuran; benzene; Ambient temperature;

DOI:10.1016/S0040-4039(00)94699-9

Reference yield: 81.0%

benzaldehyde (100-52-7) + pentan-3-one (96-22-0) → r-2,c-6-diphenyl-t-3,t-5-dimethylpiperidin-4-one (5707-11-9,18699-96-2,37418-41-0,149116-46-1)

Guidance literature:

With ammonium acetate; In ethanol; at 60 ℃; for 1h; stereospecific reaction;

DOI:10.1007/s00706-011-0576-5

upstream raw materials:

ammonium acetate

benzaldehyde

pentan-3-one

ammonium thiocyanate

Downstream raw materials:

1-(2-hydroxy-ethyl)-3t,5t-dimethyl-2r,6c-diphenyl-piperidin-4-one

3c,4,5c-trimethyl-2t,6t-diphenyl-piperidin-4r-ol

1-acetyl-3t,5t-dimethyl-2r,6c-diphenyl-piperidin-4-one

r⁽²⁾-trans-4-hydroxy-trans-3,5-dimethyl-cis-2,6-diphenylpiperidine

Refernces

• 1、 Kalaivani, Panneerselvam,Arikrishnan, Jayaraman,Gopalakrishnan, Mannuthusamy. "Design, synthesis, molecular docking and antimicrobial evaluation of some tosyl carbamate derivatives". . p. 783 - 788. Retrieved 2020/03/24.
• 2、 Sethukumar,Anand, P. Surendar,Kumar, C. Udhaya,Prakasam, B. Arul. "Synthesis, stereochemical and biological studies of some N-cyclohexylcarbamoyl -2,6-diarylpiperidin-4-ones". . p. 352 - 362. Retrieved 2016/11/04.