9H-Xanthene-9-carboxylic acid 2-(diethylamino)ethyl ester

Base Information

• Chemical Name: 9H-Xanthene-9-carboxylic acid 2-(diethylamino)ethyl ester
• CAS No.: 24539-72-8
• Molecular Formula: C20H23 N O3
• Molecular Weight: 325.408
• Mol file: 24539-72-8.mol

Synonyms:Xanthene-9-carboxylicacid, 2-(diethylamino)ethyl ester (6CI,8CI); NSC 108248; SC 920

Chemical Property of 9H-Xanthene-9-carboxylic acid 2-(diethylamino)ethyl ester

Chemical Property:

• Vapor Pressure: 1.27E-07mmHg at 25°C
• Boiling Point: 430.7°Cat760mmHg
• Flash Point: 214.3°C
• PSA: 38.77000
• Density: 1.143g/cm³
• LogP: 3.80920

Purity/Quality:

99%min ^*data from raw suppliers

Xanthene-9-carboxylicAcid2-(Diethylamino)ethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Xanthene-9-carboxylic Acid 2-(Diethylamino)ethyl Ester is an intermediate in the synthesis of Ulcine Bromide (U700650). Ulcine is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.

Technology Process of 9H-Xanthene-9-carboxylic acid 2-(diethylamino)ethyl ester

There total 6 articles about 9H-Xanthene-9-carboxylic acid 2-(diethylamino)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

xanthene-9-carboxylic acid (82-07-5) + 2-(diethylamino)ethyl chloride (100-35-6) → N,N-diethylaminoethyl xanthene-9-carboxylate (24539-72-8)

Guidance literature:

With isopropyl alcohol;

DOI:10.1021/ja01248a038

Reference yield:

xanthene (92-83-1) → N,N-diethylaminoethyl xanthene-9-carboxylate (24539-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: butyl lithium; diethyl ether / anschliessend behandeln mit festem Kohlendioxid

2: isopropyl alcohol

With n-butyllithium; diethyl ether; isopropyl alcohol;

DOI:10.1021/ja01248a038

Reference yield:

xanthene-9-carboxylic acid (82-07-5) → N,N-diethylaminoethyl xanthene-9-carboxylate (24539-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloromethane; sulfuric acid

With tetrachloromethane; sulfuric acid;

upstream raw materials:

xanthene

carbonic acid bis-(2-diethylamino-ethyl ester)

xanthene-9-carboxylic acid

2-(diethylamino)ethyl chloride

Downstream raw materials:

diethyl-methyl-[2-(xanthene-9-carbonyloxy)-ethyl]-ammonium; chloride

methantheline bromide

Refernces

• 1、 Bowden,Young. "Structure-activity relations. I. Series of antagonists of acetylcholine and histamine at the postganglionic receptors.". . p. 225,226. Retrieved 2007/10/05.