2-Bromonicotinic acid

Base Information

• Chemical Name: 2-Bromonicotinic acid
• CAS No.: 35905-85-2
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.007
• Hs Code.: 29173990
• Mol file: 35905-85-2.mol

Synonyms:2-Bromopyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 2-bromo-;

Chemical Property of 2-Bromonicotinic acid

Chemical Property:

• Appearance/Colour: Light yellow cryst.
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 200-203 °C(lit.)
• Refractive Index: 1.617
• Boiling Point: 339.35 °C at 760 mmHg
• PKA: 2.12±0.10(Predicted)
• Flash Point: 159.033 °C
• PSA: 50.19000
• Density: 1.814 g/cm³
• LogP: 1.54230
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2-Bromonicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromonicotinic acid

There total 8 articles about 2-Bromonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromopyridine-3-carboxaldehyde (128071-75-0) → 2-bromonicotinic acid (35905-85-2)

Guidance literature:

With potassium permanganate; In water; Ambient temperature;

DOI:10.1016/S0040-4039(00)93486-5

Reference yield: 98.0%

2-bromo-3-picoline (3430-17-9) → 2-bromonicotinic acid (35905-85-2)

Guidance literature:

With potassium permanganate; water; for 20h; Heating;

DOI:10.1021/ol070011y

Reference yield: 75.0%

→ 2-bromonicotinic acid (35905-85-2) + N,N-dicyclohexylurea (64407-57-4)

Guidance literature:

upstream raw materials:

2-bromo-3-picoline

bromo-2 butyl-3 pyridine

2-bromo-pyridine

carbon dioxide

Downstream raw materials:

2-bromonicotinic acid methyl ester

2-bromonicotinamide

2-hydroxy-3-carboxypyridine

2-bromo-5-(hydroxymethyl)pyridine

Refernces

• 1、 Bozkurt, Ebru,Dogan, Sengul Dilem. "Photophysical behavior of a novel 4-aza-indole derivative in different solvents: reverse solvatochromism". . p. 863 - 872. Retrieved 2018/11/01.
• 2、 Do?an, Sengul Dilem,Demirpolat, Eren,Yerer Aycan, Mükerrem Betül,Balci, Metin. "Synthesis of new 4-aza-indoles via acyl azides". . p. 252 - 258. Retrieved 2015/02/02.