2-Pyridylformaldehyde semicarbazone

Base Information

• Chemical Name: 2-Pyridylformaldehyde semicarbazone
• CAS No.: 13370-79-1
• Molecular Formula: C7H8 N4 O
• Molecular Weight: 164.167
• Hs Code.: 2933990090
• European Community (EC) Number: 236-441-2
• Mol file: 13370-79-1.mol

Synonyms:2-Pyridylformaldehyde semicarbazone;13370-79-1;[(E)-pyridin-2-ylmethylideneamino]urea;EINECS 236-441-2;SCHEMBL13826730;AKOS008939407

Chemical Property of 2-Pyridylformaldehyde semicarbazone

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 80.37000
• Density: 1.31g/cm³
• LogP: 1.17500
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 164.06981089
• Heavy Atom Count: 12
• Complexity: 180

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C=NNC(=O)N
• Isomeric SMILES: C1=CC=NC(=C1)/C=N/NC(=O)N

Technology Process of 2-Pyridylformaldehyde semicarbazone

There total 3 articles about 2-Pyridylformaldehyde semicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

pyridine-2-carbaldehyde (1121-60-4) + N4-semicarbazide hydrochloride → 2-(pyridin-2-ylmethylidene)hydrazinecarboxamide (13370-79-1)

Guidance literature:

In methanol; at 1 ℃; Reflux;

DOI:10.1016/j.poly.2014.03.027

Reference yield: 80.0%

pyridine-2-carbaldehyde (1121-60-4) + semicarbazide hydrochloride (563-41-7) → 2-(pyridin-2-ylmethylidene)hydrazinecarboxamide (13370-79-1)

Guidance literature:

Reflux;

DOI:10.1016/j.molstruc.2016.10.081

Reference yield: 80.0%

pyridine-2-carbaldehyde (1121-60-4) + hydrazine carboxamide (4426-72-6,51433-48-8,57-56-7) → 2-(pyridin-2-ylmethylidene)hydrazinecarboxamide (13370-79-1)

Guidance literature:

Reflux;

DOI:10.1080/00958972.2013.764413

upstream raw materials:

pyridine-2-carbaldehyde

semicarbazide hydrochloride

hydrazine carboxamide

Downstream raw materials:

2-[(2,4-dioxo-3-{[pyridin-2-ylmethylene]amino}imidazolidin-1-yl)(4-hydroxyphenyl)methyl]hydrazinecarbothioamide

2-[(2,4-dioxo-3-{[pyridin-2-ylmethylene]amino}imidazolidin-1-yl)(4-nitrophenyl)methyl]hydrazinecarbothioamide

2-[(2,4-dioxo-3-{[pyridin-2-ylmethylene]amino}imidazolidin-1-yl)(4-methoxyphenyl)methyl]hydrazinecarbothioamide

2-[(2,4-dioxo-3-{[pyridin-2-ylmethylene]amino}imidazolidin-1-yl)(4-dimethylaminophenyl)methyl]hydrazinecarbothioamide

Refernces

• 1、 Shaabani, Behrouz,Akbar Khandar, Ali,Dusek, Michal,Pojarova, Michaela,Mahmoudi, Farzaneh,Feher, Alexander,Kajnakova, Marcela. "Two coordination polymers based on semicarbazone Schiff base and azide: Synthesis, crystal structure, electrochemistry, magnetic properties and biological activity". . p. 748 - 762. Retrieved 2013.
• 2、 Das, Mithun,Ghosh, Biswa Nath,Rissanen, Kari,Chattopadhyay, Shouvik. "Anion modulated structural variations in copper(II) complexes with a semicarbazone Schiff base: Synthesis, characterization and self assembly". . p. 103 - 114. Retrieved 2014.
• 3、 Naclerio, George A.,Abutaleb, Nader S.,Li, Daoyi,Seleem, Mohamed N.,Sintim, Herman O.. "Ultrapotent Inhibitor of Clostridioides difficile Growth, Which Suppresses Recurrence in Vivo". . p. 11934 - 11944. Retrieved 2020/11/26.