Technology Process of 6-Heptenoic acid,
7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,
1,1-dimethylethyl ester, (3S,5R,6E)-
There total 5 articles about 6-Heptenoic acid,
7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-,
1,1-dimethylethyl ester, (3S,5R,6E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; diethyl methoxy borane;
In
tetrahydrofuran; methanol;
at -78 ℃;
for 3h;
DOI:10.1016/S0040-4020(97)00686-8
- Guidance literature:
-
Multi-step reaction with 4 steps
2: tetramethylammonium triacetoxyborohydride, acetic acid / acetonitrile / 2 h / -10 °C
3: DDQ / tetrahydrofuran / Ambient temperature
4: 82 percent / NaBH4, Et2BOMe / tetrahydrofuran; methanol / 3 h / -78 °C
With
sodium tetrahydroborate; diethyl methoxy borane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(97)00686-8
- Guidance literature:
-
Multi-step reaction with 4 steps
2: tetramethylammonium triacetoxyborohydride, acetic acid / acetonitrile / 2 h / -10 °C
3: DDQ / tetrahydrofuran / Ambient temperature
4: 82 percent / NaBH4, Et2BOMe / tetrahydrofuran; methanol / 3 h / -78 °C
With
sodium tetrahydroborate; diethyl methoxy borane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride;
In
tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(97)00686-8