2-chloro-N-(4-methoxyphenyl)benzamide

Base Information

• Chemical Name: 2-chloro-N-(4-methoxyphenyl)benzamide
• CAS No.: 7508-77-2
• Molecular Formula: C14H12 Cl N O2
• Molecular Weight: 261.708
• Hs Code.: 2924299090
• European Community (EC) Number: 667-601-3
• NSC Number: 404942
• DSSTox Substance ID: DTXSID80323820
• Wikidata: Q82083055
• Mol file: 7508-77-2.mol

Synonyms:2-chloro-N-(4-methoxyphenyl)benzamide;7508-77-2;NSC 404942;Benzamide, N-(4-methoxyphenyl)-2-chloro-;NSC404942;Oprea1_594551;SCHEMBL6300537;DTXSID80323820;MFCD00018260;AKOS001604726;2-CHLORO-4'-METHOXYBENZANILIDE;NSC-404942;CS-0302846;EU-0069615;AH-034/01369064;SR-01000414635;SR-01000414635-1;Z28138913

Chemical Property of 2-chloro-N-(4-methoxyphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.000187mmHg at 25°C
• Boiling Point: 328.6°Cat760mmHg
• Flash Point: 152.6°C
• PSA: 38.33000
• Density: 1.281g/cm³
• LogP: 3.67390
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 261.0556563
• Heavy Atom Count: 18
• Complexity: 277

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-4'-METHOXYBENZANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC(=O)C2=CC=CC=C2Cl

Technology Process of 2-chloro-N-(4-methoxyphenyl)benzamide

There total 2 articles about 2-chloro-N-(4-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ N-(o-chlorobenzoyl)-4-methoxyaniline (7508-77-2)

Guidance literature:

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → N-(o-chlorobenzoyl)-4-methoxyaniline (7508-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 5 h / Reflux

2: triethylamine / ethyl acetate / 1 h / 0 - 20 °C

With thionyl chloride; triethylamine; In ethyl acetate;

DOI:10.1002/ejoc.201101400

Reference yield: 87.0%

N-(o-chlorobenzoyl)-4-methoxyaniline (7508-77-2) + phenylacetylene (536-74-3) → 3-phenylmethylene-2-(4-methoxyphenyl)isoindole-1-one (91233-33-9)

Guidance literature:

With 1,10-Phenanthroline; copper(II) oxide; potassium carbonate; In acetonitrile; at 90 ℃; Inert atmosphere;

upstream raw materials:

ortho-chlorobenzoic acid

Downstream raw materials:

2-methoxyphenanthridin-6(5H)-one

C₁₅H₁₄ClNO₂

3-phenylmethylene-2-(4-methoxyphenyl)isoindole-1-one

Refernces

• 1、 -. "Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents". Page/Page column 7. . Retrieved 2008/06/13.