4-(2-Bromopropyl)-1,2-dimethoxybenzene

Base Information

• Chemical Name: 4-(2-Bromopropyl)-1,2-dimethoxybenzene
• CAS No.: 19578-93-9
• Molecular Formula: C11H15BrO2
• Molecular Weight: 259.143
• DSSTox Substance ID: DTXSID501283733
• Mol file: 19578-93-9.mol

Synonyms:4-(2-bromopropyl)-1,2-dimethoxybenzene;19578-93-9;SCHEMBL3469321;UGTFRYYLKFTUMT-UHFFFAOYSA-N;DTXSID501283733;2-bromo-4,5-dimethoxypropylbenzene;AKOS012315887;CS-0302607;EN300-1897786

Chemical Property of 4-(2-Bromopropyl)-1,2-dimethoxybenzene

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 258.02554
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)OC)OC)Br

Technology Process of 4-(2-Bromopropyl)-1,2-dimethoxybenzene

There total 4 articles about 4-(2-Bromopropyl)-1,2-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,2-dimethoxy-4-(2-propenyl)benzene (93-15-2) → 1-(3,4-dimethoxyphenyl)-2-bromopropane (19578-93-9)

Guidance literature:

With hydrogen bromide; In acetic acid; at 0 ℃;

Reference yield:

4-allylguaiacol (97-53-0) → 1-(3,4-dimethoxyphenyl)-2-bromopropane (19578-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / K₂CO₃ / acetone / 6 h / Heating

2: 65 percent / HBr / acetic acid / 0 °C

With hydrogen bromide; potassium carbonate; In acetic acid; acetone;

Reference yield:

3,4-dimethoxyphenylacetone (776-99-8) → 1-(3,4-dimethoxyphenyl)-2-bromopropane (19578-93-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / bis-(2-methoxy-ethyl) ether

2: HBr, Py / benzene; petroleum ether

With pyridine; sodium tetrahydroborate; hydrogen bromide; In diethylene glycol dimethyl ether; Petroleum ether; benzene;

upstream raw materials:

1,2-dimethoxy-4-(2-propenyl)benzene

4-allylguaiacol

3,4-dimethoxyphenylacetone

Downstream raw materials:

1-(3,4-Dimethoxy-phenyl)-2-propyl-(2-methoxy-phenyl)-ether

Refernces

• 1、 Gunasekaran, A.,Balasubramanian, K.. "Syntheses of (+/-)-Deoxyschizandrin and the Lignan, 1,4-Bis(3,4-dimethoxyphenyl)-2,3-dimethylbutane". . p. 308 - 310. Retrieved 2007/10/02.