Methyl 2-broMo-3,4,5-triMethoxybenzoate

Base Information

• Chemical Name: Methyl 2-broMo-3,4,5-triMethoxybenzoate
• CAS No.: 1968-71-4
• Molecular Formula: C11H13BrO5
• Molecular Weight: 305.125
• Mol file: 1968-71-4.mol

Synonyms:Trimethylaetherbromgallussaeure-methylester;Butanoic acid,2-bromo-3,3-dimethyl-,methyl ester;2-bromo-3,4,5-trimethoxy-benzoic acid methyl ester;2-Brom-3,4,5-trimethoxy-benzoesaeure-methylester;3.3-Dimethyl-2-brom-buttersaeuremethylester;3,4,5-Trimethoxy-2-brom-benzoesaeure-methylester;2-bromo-3,4,5-trimethoxybenzoate;

Chemical Property of Methyl 2-broMo-3,4,5-triMethoxybenzoate

Chemical Property:

• PSA: 53.99000
• LogP: 2.26150

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-broMo-3,4,5-triMethoxybenzoate

There total 8 articles about Methyl 2-broMo-3,4,5-triMethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,4,5-trimethoxybenzoic acid methyl ester (1916-07-0) → methyl 2-bromo-3,4,5-trimethoxybenzoate (1968-71-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c6ob01977c

Reference yield: 94.0%

methanol (67-56-1) + 2-bromo-3,4,5-trimethoxybenzoic acid (23346-82-9) → methyl 2-bromo-3,4,5-trimethoxybenzoate (1968-71-4)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 48h;

DOI:10.1039/c4ob01476f

Reference yield:

Eudesmic acid (118-41-2) → methyl 2-bromo-3,4,5-trimethoxybenzoate (1968-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂SO₄

2: 84 percent / Br₂ / CHCl₃

With sulfuric acid; bromine; In chloroform;

upstream raw materials:

diazomethane

2-bromo-4-hydroxy-3,5-dimethoxy-benzoic acid methyl ester

methanol

2-bromo-3,4,5-trimethoxybenzoic acid

Downstream raw materials:

dimethyl 3-benzyloxy-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

urolithin M6

C₃₃H₆₀O₉Si₂

methyl 2-{(4aR,8R,8aR)-2,2-di-tert-butyl-8-[(triisopropylsilyl)oxy]-4,4a,8,8a-tetrahydropyrano[3,2-d][1,3,2]dioxasilin-6-yl}-3,4,5-trimethoxybenzoate

Refernces

• 1、 Denol, Thibaut,Zervosen, Astrid,Lemaire, Christian,Joris, Bernard,Herv, Mireille,Blanot, Didier,Zaragoza, Guillermo,Luxen, Andr. "Enantioselective synthesis of α-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan". supporting information. p. 9853 - 9863. Retrieved 2015/01/09.
• 2、 Wu, Gang,Guo, Huan-Fang,Gao, Kun,Liu, Yi-Nan,Bastow, Kenneth F.,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung,Xie, Lan. "Synthesis of unsymmetrical biphenyls as potent cytotoxic agents". scheme or table. p. 5272 - 5276. Retrieved 2009/05/07.