Givinostat hydrochloride

Base Information

• Chemical Name: Givinostat hydrochloride
• CAS No.: 199657-29-9
• Deprecated CAS: 383198-22-9
• Molecular Formula: C24H27N3O4.ClH
• Molecular Weight: 457.957
• UNII: Z02132R2QQ
• NCI Thesaurus Code: C1946
• Wikidata: Q27294820
• Mol file: 199657-29-9.mol

Synonyms:givinostat hydrochloride;ITF 2357;ITF2357

Chemical Property of Givinostat hydrochloride

Chemical Property:

• PSA: 90.90000
• LogP: 5.81520
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 457.1768341
• Heavy Atom Count: 32
• Complexity: 575

Purity/Quality:

99%, ^*data from raw suppliers

Givinostathydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.Cl
• Recent ClinicalTrials: Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera
• Recent EU Clinical Trials: A randomised, double-blind, placebo-controlled study to evaluate the micro-macroscopic effects on muscles, the safety and tolerability, and the efficacy of

Technology Process of Givinostat hydrochloride

There total 1 articles about Givinostat hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-(6-diethylaminomethyl-naphtalen-2-ylmethoxycarbonylamino)-benzoic acid (199657-47-1) → diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride (199657-29-9)

Guidance literature:

4-(6-diethylaminomethyl-naphtalen-2-ylmethoxycarbonylamino)-benzoic acid; With thionyl chloride; In tetrahydrofuran; at 0 - 10 ℃; for 1h; Heating / reflux;

N,N-dimethyl-formamide; In tetrahydrofuran; for 1h; Heating / reflux;

With hydrogenchloride; hydroxylamine; more than 3 stages;

upstream raw materials:

4-(6-diethylaminomethyl-naphtalen-2-ylmethoxycarbonylamino)-benzoic acid

Refernces