1H-Imidazole-2-carboxaldehyde, 1-methyl-, oxime

Base Information

• Chemical Name: 1H-Imidazole-2-carboxaldehyde, 1-methyl-, oxime
• CAS No.: 20062-62-8
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.12900
• Mol file: 20062-62-8.mol

Synonyms:N-methyl-2-imidazolyloxime;1-methyl-1H-imidazole-2-carbaldehyde oxime;1-methylimidazole-2-carbaldehyde oxime;1H-Imidazole-2-carboxaldehyde,1-methyl-,oxime;1-methylimidazole-2-aldoxime;1-methyl-2-imidazolecarbaldehyde oxime;

Chemical Property of 1H-Imidazole-2-carboxaldehyde, 1-methyl-, oxime

Chemical Property:

• PSA: 50.15000
• LogP: 0.13870

Purity/Quality:

99% ^*data from raw suppliers

1-methyl-1H-imidazole-2-carbaldehydeoxime 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-2-carboxaldehyde, 1-methyl-, oxime

There total 4 articles about 1H-Imidazole-2-carboxaldehyde, 1-methyl-, oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-<(hydroxyimino)methyl>-1-methylimidazole (20062-62-8)

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; water; for 0.166667h; Microwave irradiation;

DOI:10.1590/S0103-50532012000700004

Reference yield: 87.0%

N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-<(hydroxyimino)methyl>-1-methylimidazole (20062-62-8)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; for 3h; Heating;

DOI:10.1039/b300001j

Reference yield: 44.0%

hydroxylamine hydrochloride (5470-11-1) + N-methyl-2-imidazolcarboxaldehyde (13750-81-7) → 2-<(hydroxyimino)methyl>-1-methylimidazole (20062-62-8)

Guidance literature:

With sodium acetate; In water; for 1h;

upstream raw materials:

N-methyl-2-imidazolcarboxaldehyde

hydroxylamine hydrochloride

Downstream raw materials:

1-<(benzyloxy)methyl>-2-<(hydroxyimino)methyl>-3-methylimidazolium chloride

1-<(1'-hexyloxy)methyl>-2-<(hydroxyimino)methyl>-3-methylimidazolium chloride

2-(Hydroxyimino-methyl)-1-methyl-3-(3-methyl-butoxymethyl)-3H-imidazol-1-ium; chloride

1,1'-bis<4-<(hydroxyimino)methyl>-3-methyl-1H-imidazolium chloride>

Refernces

• 1、 Foti,Grassi,Risitano,La Rosa. "Synthesis of 3-imidazolylazole derivatives from a new nitrile oxide [1]". . p. 539 - 540. Retrieved 2001.
• 2、 Sharma, Rahul,Gupta, Bhanushree,Sahu, Arvind Kumar,Acharya, Jyotiranjan,Satnami, Manmohan L.,Ghosh, Kallol K.. "Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE)". . p. 85 - 92. Retrieved 2016/12/09.
• 3、 Ferri, Nicola,Cazzaniga, Stefano,Mazzarella, Luca,Curigliano, Giuseppe,Lucchini, Giorgio,Zerla, Daniele,Gandolfi, Raffaella,Facchetti, Giorgio,Pellizzoni, Michela,Rimoldi, Isabella. "Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes on human carcinoma cell lines: A comparative study with cisplatin". . p. 2379 - 2386. Retrieved 2013/05/09.