5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE

Base Information

• Chemical Name: 5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE
• CAS No.: 68208-09-3
• Molecular Formula: C₈H₁₁NO₄
• Molecular Weight: 185.18
• Hs Code.: 2934999090
• Mol file: 68208-09-3.mol

Synonyms:5-Ethoxy-2-ethoxycarbonyloxazole;

Chemical Property of 5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE

Chemical Property:

• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 260.8 °C at 760 mmHg
• Flash Point: 111.5 °C
• PSA: 61.56000
• Density: 1.154 g/cm³
• LogP: 1.25000

Purity/Quality:

99% ^*data from raw suppliers

5-Ethoxy-2-OxazolecarboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE is a 5-alkoxyoxazoles, which is shown to be able to used in theDiels-Alder process, and thus plays important role in organic synthesis. 5-Ethoxy-2-Oxazolecarboxylic Acid Ethyl Ester, is a 5-alkoxyoxazoles, which is shown to be able to used in theDiels-Alder process, and thus plays important role in organic synthesis.

Technology Process of 5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE

There total 2 articles about 5-ETHOXY-2-ETHOXYCARBONYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

[(2-ethoxy-2-oxoethyl)amino]oxoacetic acid ethyl ester (29655-79-6) → 5-ethoxy-2-ethoxycarbonyloxazole (68208-09-3)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; Triphenylphosphine oxide; In toluene; at 25 - 55 ℃; for 3h;

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + oxalic acid diethyl ester (95-92-1) → 5-ethoxy-2-ethoxycarbonyloxazole (68208-09-3)

Guidance literature:

Multistep reaction; (i) Et₃N, EtOH, (ii) POCl₃, Et₃N;

Reference yield: 90.0%

5-ethoxy-2-ethoxycarbonyloxazole (68208-09-3) → 5-ethoxy-oxazole-2-carboxylic acid (68208-10-6)

Guidance literature:

With sodium hydroxide; In water; for 1h; Ambient temperature;

DOI:10.1002/jhet.5570320605

upstream raw materials:

glycine ethyl ester hydrochloride

oxalic acid diethyl ester

[(2-ethoxy-2-oxoethyl)amino]oxoacetic acid ethyl ester

Downstream raw materials:

(5-ethoxy-oxazol-2-yl)-methanol

5-ethoxy-oxazole-2-carboxylic acid

5-ethoxyoxazole

Refernces

• 1、 -. "INTEGRASE INHIBITORS 3". Page/Page column 63. . Retrieved 2008/06/13.
• 2、 Krapcho,Maresch,Gallagher,Hacker,Menta,Oliva,Di Domenico,Da Re,Spinelli. "Synthesis of 4-hydroxy-6,9-difluorobenz[g]isoquinoline-5,10-diones and conversions to 4-hydroxy-6,9-bis[(aminoalkyl)amino]-benz[g]isoquinoline-5,10-diones". . p. 1693 - 1702. Retrieved 2007/10/03.