4-(2-Piperidin-1-yl-ethoxy)benzyl chloride

Base Information Edit

Chemical Name:4-(2-Piperidin-1-yl-ethoxy)benzyl chloride
CAS No.:206550-68-7
Molecular Formula:C14H20ClNO
Molecular Weight:253.772
Hs Code.:
DSSTox Substance ID:DTXSID90432018
Wikidata:Q82246082
Mol file:206550-68-7.mol

Synonyms:4-(2-piperidin-1-yl-ethoxy)benzyl chloride;206550-68-7;1-(2-(4-(Chloromethyl)phenoxy)ethyl)piperidine;SCHEMBL1983832;DTXSID90432018;CVXCWPZVOYBWOJ-UHFFFAOYSA-N;4-(2-piperidin-1-yl-ethoxy)-benzyl chloride;1-[2-(4-chloromethylphenoxy)ethyl]-piperidine;1-[2-(4chloromethylphenoxy)-ethyl]-piperidine;1-[2-(4-chloromethylphenoxy)-ethyl]-piperidine;1-[2-(4-chloromethyl-phenoxy)-ethyl]-piperidine

Suppliers and Price of 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride Edit

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:253.1233420
Heavy Atom Count:17
Complexity:198

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CCOC2=CC=C(C=C2)CCl

Technology Process of 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride

There total 6 articles about 4-(2-Piperidin-1-yl-ethoxy)benzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 223251-13-6
[4-[2-(1-piperidinyl)ethoxy]phenyl]methanol

: 206550-68-7
1-[2-(4-Chloromethyl-phenoxy)-ethyl]-piperidine

Guidance literature:: [4-[2-(1-piperidinyl)ethoxy]phenyl]methanol; With hydrogenchloride; In tetrahydrofuran; at 0 ℃;

With thionyl chloride; In tetrahydrofuran; at 50 ℃;
DOI:10.1016/j.bmcl.2005.03.111

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 206550-68-7
1-[2-(4-Chloromethyl-phenoxy)-ethyl]-piperidine

Guidance literature:: With thionyl chloride; sodium borohydrid; potassium carbonate; In tetrahydrofuran; methanol; N-chloroethylpiperidine hydrochloride;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 206550-68-7
1-[2-(4-Chloromethyl-phenoxy)-ethyl]-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 120 °C

2.1: NaBH₄ / methanol / 20 °C

3.1: tetrahydrofuran / Heating

4.1: HCl (gas) / tetrahydrofuran / 0 °C

4.2: SOCl₂ / tetrahydrofuran / 50 °C

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.03.111