1-Phenyl-2-methyl-1-butanone

Base Information

• Chemical Name: 1-Phenyl-2-methyl-1-butanone
• CAS No.: 938-87-4
• Molecular Formula: C11H14O
• Molecular Weight: 162.232
• Hs Code.: 2914399090
• Mol file: 938-87-4.mol

Synonyms:2-Methyl-1-phenyl-1-butanone;sec-butyl phenyl ketone;rac-2-methyl butyrophenone;1-Butanone,2-methyl-1-phenyl;s-butyl phenyl ketone;2-Methyl-1-phenyl-butan-1-on;2-methyl-1-phenyl-butan-1-one;(+-)-2-methyl-1-phenyl-butanone-(1);

Chemical Property of 1-Phenyl-2-methyl-1-butanone

Chemical Property:

• Vapor Pressure: 0.0532mmHg at 25°C
• Boiling Point: 234.3°Cat760mmHg
• Flash Point: 89.7°C
• PSA: 17.07000
• Density: 0.949g/cm³
• LogP: 2.91540

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenyl-2-methyl-1-butanone

There total 74 articles about 1-Phenyl-2-methyl-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + propiophenone (495-40-9) → 2-methyl-1-phenyl-butan-1-one (938-87-4)

Guidance literature:

With trimethylamine-N-oxide; tricarbonyl(η⁴-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; potassium carbonate; at 80 ℃; for 24h; Reagent/catalyst; Temperature; Catalytic behavior;

DOI:10.1021/acscatal.8b02158

Reference yield: 98.0%

2-methylbutanoic anhydride (1519-23-9) + phenylboronic acid (98-80-6) → 2-methyl-1-phenyl-butan-1-one (938-87-4)

Guidance literature:

With palladium diacetate; P(p-CH₃OC₆H₄)3; at 60 ℃; for 16h;

DOI:10.1002/1521-3773(20010917)40:18<3458::AID-ANIE3458>3.0.CO;2-0

Reference yield: 97.0%

s-butyl chloride (78-86-4,53178-20-4) + benzoic acid (65-85-0,8013-63-6) → 2-methyl-1-phenyl-butan-1-one (938-87-4)

Guidance literature:

With naphthalene; lithium; In tetrahydrofuran; at 0 - 20 ℃; for 0.166667h;

DOI:10.1021/jo9605962

upstream raw materials:

2-methyl-1-phenylbutan-1-ol

2-ethyl-2-methyl-1-phenyl-propane-1,3-diol

ethyl iodide

1-phenyl-propan-1-one

Downstream raw materials:

2-bromo-2-methyl-1-phenylbutan-1-one

2,2-dimethyl-1-phenylbutanone

2-ethyl-5-chloro-2-methyl-1-phenyl-pentan-1-one

Trimethyl-((E)-2-methyl-1-phenyl-but-1-enyloxy)-silane

Refernces

• 1、 Biswal, Priyabrata,Samser, Shaikh,Meher, Sushanta Kumar,Chandrasekhar, Vadapalli,Venkatasubbaiah, Krishnan. "Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol". supporting information. p. 413 - 419. Retrieved 2021/11/01.
• 2、 Zhou, Fangyuan,Li, Lesong,Lin, Kao,Zhang, Feng,Deng, Guo-Jun,Gong, Hang. "Iron-Catalyzed Cleavage Reaction of Keto Acids with Aliphatic Aldehydes for the Synthesis of Ketones and Ketone Esters". supporting information. p. 4246 - 4250. Retrieved 2020/03/11.