Propanedioic acid, [(4-chlorophenyl)methyl]-

Base Information

• Chemical Name: Propanedioic acid, [(4-chlorophenyl)methyl]-
• CAS No.: 21405-64-1
• Molecular Formula: C10H9ClO4
• Molecular Weight: 228.632
• Mol file: 21405-64-1.mol

Synonyms:p-Chlorbenzylmalonsaeure;4-chlorobenzylmalonic acid;p-Chlorobenzylmalonic Acid;

Chemical Property of Propanedioic acid, [(4-chlorophenyl)methyl]-

Chemical Property:

• PSA: 74.60000
• LogP: 1.66790

Purity/Quality:

95+% ^*data from raw suppliers

(4-Chlorobenzyl)propanedioicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, [(4-chlorophenyl)methyl]-

There total 8 articles about Propanedioic acid, [(4-chlorophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

p-chlorobenzylidenepropane-1,3-dioic acid (17449-02-4) → <(4-chlorophenyl)methyl>propanedioic acid (21405-64-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 2585.7 Torr;

DOI:10.1021/jm00041a026

Reference yield:

diethyl (4-chlorobenzyl)malonate (37556-13-1) → <(4-chlorophenyl)methyl>propanedioic acid (21405-64-1)

Guidance literature:

Reference yield:

2,2-dimethyl-5-(4-chlorophenyl)methyl-1,3-dioxane-4,6-dione (88466-67-5) → <(4-chlorophenyl)methyl>propanedioic acid (21405-64-1)

Guidance literature:

With water; sodium hydroxide; at 120 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

diethyl (4-chlorobenzyl)malonate

p-chlorobenzylidenepropane-1,3-dioic acid

4-chlorobenzyl bromide

4-chlorobenzaldehyde

Downstream raw materials:

(4-chloro-benzyl)-piperidinomethyl-malonic acid

6-bromo-2,4-dichloro-3-(4-chlorobenzyl)quinoline

C₁₉H₁₈ClNO

C₁₄H₁₂ClN₃O₂S

Refernces

• 1、 -. "METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt". . . Retrieved 2014/05/07.
• 2、 Kawasaki, Masashi,Goto, Michimasa,Kawabata, Shigeki,Kometani, Tadashi. "The effect of vinyl esters on the enantioselectivity of the lipase-catalysed transesterification of alcohols". . p. 585 - 596. Retrieved 2007/10/03.