1-Cyclohexene-1-acetic acid, a-methyl-

Base Information

• Chemical Name: 1-Cyclohexene-1-acetic acid, a-methyl-
• CAS No.: 2205-24-5
• Molecular Formula: C9H14O2
• Molecular Weight: 154.209
• Mol file: 2205-24-5.mol

Synonyms:

Chemical Property of 1-Cyclohexene-1-acetic acid, a-methyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Cyclohexene-1-acetic acid, a-methyl-

There total 10 articles about 1-Cyclohexene-1-acetic acid, a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methyl-1-oxaspiro<3.5>nonan-2-one (121821-93-0) → 2-cyclohex-1-enyl-propionic acid (2205-24-5)

Guidance literature:

With magnesium bromide; In diethyl ether; for 6h; Ambient temperature;

DOI:10.1016/S0040-4020(01)82011-1

Reference yield: 65.0%

ethyl 2-(1-hydroxycyclohexyl)propionate (39922-60-6) → 2-cyclohex-1-enyl-propionic acid (2205-24-5) + ethyl 2-cyclohexilidenepropionate (63963-01-9)

Guidance literature:

ethyl 2-(1-hydroxycyclohexyl)propionate; With pyridine; thionyl chloride; In diethyl ether; at 20 ℃; for 48h;

With sodium hydroxide; In ethanol; water; at 30 ℃; for 0.333333h; Further stages.;

DOI:10.1021/jo011178m

Reference yield: 43.0%

2-(1-Cyclohex-1-enyl-ethyl)-2-hydroxy-malonic acid (90107-25-8) → 2-cyclohex-1-enyl-propionic acid (2205-24-5)

Guidance literature:

With pyridine; sodium periodate; for 1h;

DOI:10.1021/ja00527a064

upstream raw materials:

2-(1'-Cyclohexenyl)-2-methyl-acetonitrile

3-methyl-1-oxaspiro<3.5>nonan-2-one

2-(1-Cyclohex-1-enyl-ethyl)-2-hydroxy-malonic acid

2-cyclohexylidenepropanoic acid

Downstream raw materials:

methyl 2-(1-cyclohexenyl)propanoate

2-Cyclohex-1-enyl-propionyl chloride

carbon dioxide

ethylidenecyclohexane

Refernces

• 1、 Black, T. Howard,Eisenbeis, Shane A.,McDermott, Todd S.,Maluleka, Stephen L.. "SYNTHETIS OF CYCLIC AND ACYCLIC β,γ-UNSATURATED CARBOXYLIC ACIDS VIA AN E1-TYPE IONIZATION/ELIMINATION OF β-LACTONES". . p. 2307 - 2316. Retrieved 2007/10/02.
• 2、 Salomon, Mary F.,Pardo, Simon N.,Salomon, Robert G.. "Enecarboxylation with Diethyl Oxomalonate as an Enophilic Equivalent of Carbon Dioxide. A Synthesis of Allylcarboxylic Acids". . p. 3797 - 3802. Retrieved 2007/10/02.