(e)-1-(3,5-Difluorophenyl)-2-phenyldiazene

Base Information

• Chemical Name: (e)-1-(3,5-Difluorophenyl)-2-phenyldiazene
• CAS No.: 3896-24-0
• Molecular Formula: C₁₂H₈F₂N₂
• Molecular Weight: 218.206
• NSC Number: 83331
• DSSTox Substance ID: DTXSID10292515
• Mol file: 3896-24-0.mol

Synonyms:3896-24-0;(e)-1-(3,5-difluorophenyl)-2-phenyldiazene;NSC83331;DTXSID10292515;NSC-83331

Chemical Property of (e)-1-(3,5-Difluorophenyl)-2-phenyldiazene

Chemical Property:

• Vapor Pressure: 0.00122mmHg at 25°C
• Boiling Point: 308.7°Cat760mmHg
• Flash Point: 140.5°C
• Density: 1.18g/cm³
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.06555459
• Heavy Atom Count: 16
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N=NC2=CC(=CC(=C2)F)F

Technology Process of (e)-1-(3,5-Difluorophenyl)-2-phenyldiazene

There total 8 articles about (e)-1-(3,5-Difluorophenyl)-2-phenyldiazene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Difluor-4'-nitro-4-amino-azobenzol (3743-89-3) → 3,5-Difluor-azobenzol (3896-24-0)

Guidance literature:

Multi-step reaction with 5 steps

1: AcOH / Heating

2: aq. N₂H₄ / Pd-C / ethanol / Heating

3: aq. HCl / Heating

4: AcOH / ethanol

5: (i) NaNO₂, H₂SO₄, AcOH, (ii) aq. H₃PO₂

With hydrogenchloride; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

Reference yield:

2,6-Difluor-4'-nitro-4-acetamido-azobenzol (3743-87-1) → 3,5-Difluor-azobenzol (3896-24-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. N₂H₄ / Pd-C / ethanol / Heating

2: aq. HCl / Heating

3: AcOH / ethanol

4: (i) NaNO₂, H₂SO₄, AcOH, (ii) aq. H₃PO₂

With hydrogenchloride; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

Reference yield:

Sodium; (3,5-difluoro-phenylamino)-methanesulfonate → 3,5-Difluor-azobenzol (3896-24-0)

Guidance literature:

Multi-step reaction with 6 steps

1: (i) NaNO₂, aq. HCl, (ii) /BRN= 7011785/

2: AcOH / Heating

3: aq. N₂H₄ / Pd-C / ethanol / Heating

4: aq. HCl / Heating

5: AcOH / ethanol

6: (i) NaNO₂, H₂SO₄, AcOH, (ii) aq. H₃PO₂

With hydrogenchloride; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

upstream raw materials:

3,5-difluoroaniline

Nitrosobenzene

3,5-Difluor-4-amino-azobenzol

2,6-difluoro-1,4-phenylenediamine

Downstream raw materials:

2,3,4-triphenyl-5,7-difluoro-8((Z)-stilbenyl)-2,3-dihydrocinnoline