6-Amino-2-methylthio-3-methyluracil

Base Information

• Chemical Name: 6-Amino-2-methylthio-3-methyluracil
• CAS No.: 54030-56-7
• Molecular Formula: C6H9N3OS
• Molecular Weight: 171.223
• Hs Code.: 29335990
• Mol file: 54030-56-7.mol

Synonyms:6-Amino-3-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one;

Chemical Property of 6-Amino-2-methylthio-3-methyluracil

Chemical Property:

• Vapor Pressure: 0.00339mmHg at 25°C
• Melting Point: 255-258 °C
• Refractive Index: 1.65
• Boiling Point: 282.3 °C at 760 mmHg
• Flash Point: 124.5 °C
• PSA: 86.21000
• Density: 1.39 g/cm³
• LogP: 0.66560
• Storage Temp.: -20°C Freezer

Purity/Quality:

98% ^*data from raw suppliers

6-Amino-2-methylthio-3-methyluracil ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 7/47-24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Amino-2-methylthio-3-methyluracil

There total 5 articles about 6-Amino-2-methylthio-3-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

2-(Methylthio)-4-hydroxy-6-aminopyrimidine (1074-41-5) + methyl iodide (74-88-4) → 6-methoxy-2-methylsulfanyl-pyrimidin-4-ylamine (3289-53-0) + 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (54030-56-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 4h;

DOI:10.1021/jm701159t

Reference yield:

6-Amino-2-thiouracil (1004-40-6) + dimethyl sulfate (77-78-1) → 6-methoxy-2-methylsulfanyl-pyrimidin-4-ylamine (3289-53-0) + 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (54030-56-7)

Guidance literature:

With sodium hydroxide; at 40 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1515/znb-1997-1214

Reference yield:

methyl iodide (74-88-4) → 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (54030-56-7)

Guidance literature:

With ethanol; sodium ethanolate;

upstream raw materials:

6-Amino-2-thiouracil

dimethyl sulfate

methyl iodide

6-amino-2-methylsulfanylpyrimidin-4(3H)-one

Downstream raw materials:

6-amino-3-methylpyrimidin-4(3H)-one

4-amino-1,6-dihydro-1-methyl-2-methylthio-5-nitroso-6-oxo-pyrimidine

N-(1-methyl-6-oxo-1,6-dihydro-pyrimidin-4-yl)-acetamide

Refernces

• 1、 Roehrkasten,Raatz,Kreher,Blaszkewicz. "Synthesis of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 5-acetylamino-6-amino-3-methyluracil (AAMU) on a preparative scale". . p. 1526 - 1532. Retrieved 2007/10/03.