3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol

Base Information

• Chemical Name: 3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol
• CAS No.: 22805-15-8
• Molecular Formula: C11H16O5
• Molecular Weight: 228.245
• Hs Code.: 2909499000
• Mol file: 22805-15-8.mol

Synonyms:W2129;

Chemical Property of 3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol

Chemical Property:

• PSA: 79.15000
• LogP: 0.30510
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Hydroxy-3,5-Dimethoxyphenyl)-1,2-Propanediol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol

There total 6 articles about 3-(4-Hydroxy-3,5-dimethoxyphenyl)-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C18H22O5 → 3-(4-hydroxy-3,5-dimethoxyphenyl) propane-1,2-diol (22805-15-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 16h; under 750.075 Torr;

Reference yield:

1,3-dimethoxy-2-hydroxy-benzene (91-10-1) → 3-(4-hydroxy-3,5-dimethoxyphenyl) propane-1,2-diol (22805-15-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium ethanolate / ethanol / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 16 h

2.1: 2 h / 230 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: AD-mix β / water; tert-butyl alcohol / 16 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 750.08 Torr

With palladium 10% on activated carbon; AD-mix β; hydrogen; sodium ethanolate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

1,3-dimethoxy-2-[(prop-2-en-1-yl)oxy]benzene (5438-54-0) → 3-(4-hydroxy-3,5-dimethoxyphenyl) propane-1,2-diol (22805-15-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 2 h / 230 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: AD-mix β / water; tert-butyl alcohol / 16 h / 20 °C

4: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 750.08 Torr

With palladium 10% on activated carbon; AD-mix β; hydrogen; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

1,3-dimethoxy-2-hydroxy-benzene

1,3-dimethoxy-2-[(prop-2-en-1-yl)oxy]benzene

4-allyl-2,6-dimethoxyphenol

Refernces