D-ribose-L-cysteine

Base Information

• Chemical Name: D-ribose-L-cysteine
• CAS No.: 232617-15-1
• Molecular Formula: C8H15NO6S
• Molecular Weight: 253.276
• UNII: 4PS0070ASU
• Nikkaji Number: J424.013H
• Mol file: 232617-15-1.mol

Synonyms:2-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4-carboxylic acid;D-ribo-2-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4-carboxylic acid;D-ribose-L-cysteine;RibCys

Chemical Property of D-ribose-L-cysteine

Chemical Property:

• Melting Point: >60°C (dec.)
• Boiling Point: 654.4±55.0 °C(Predicted)
• PKA: 1.97±0.40(Predicted)
• PSA: 138.48000
• Density: 1.624±0.06 g/cm3(Predicted)
• LogP: -2.62890
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Methanol (Slightly, Heated), Water (Slightly)
• XLogP3: -4.8
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 5
• Exact Mass: 253.06200837
• Heavy Atom Count: 16
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

D-Ribose-L-cysteine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(NC(S1)C(C(C(CO)O)O)O)C(=O)O
• Isomeric SMILES: C1[C@H](NC(S1)[C@@H]([C@@H]([C@@H](CO)O)O)O)C(=O)O
• Uses: D-Ribose-L-cysteine is a prodrug of L-cysteine that has potential therapeutic advantage in the inhibition of astrocytoma cell proliferation. D-Ribose-L-cysteine has been shown to protect against aceta minophen-induced hepatic and renal toxicity. D-Ribose-L-cysteine is a prodrug of L-cysteine that has potential therapeutic advantage in the inhibition of astrocytoma cell proliferation (1,2). D-Ribose-L-cysteine has been shown to protect against acetaminophen-induced hepatic and renal toxicity.

Technology Process of D-ribose-L-cysteine

There total 5 articles about D-ribose-L-cysteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.65%

L-Cysteine (52-90-4) + D-ribose (50-69-1) → 2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl)-thiazolidine-4(R)-carboxylic acid (232617-15-1)

Guidance literature:

In ethanol; water; at 18 - 20 ℃; for 26h; Inert atmosphere; Industry scale;

Reference yield: 92.2%

→ 2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl)-thiazolidine-4(R)-carboxylic acid (232617-15-1)

Guidance literature:

Reference yield:

D-ribose (50-69-1) + l-cysteine hydrochloride (52-89-1) → 2(R,S)-D-ribo-(1',2',3',4'-tetrahydroxybutyl)-thiazolidine-4(R)-carboxylic acid (232617-15-1)

Guidance literature:

upstream raw materials:

D-ribose

l-cysteine hydrochloride

L-Cysteine

pyridine

Downstream raw materials:

(2Ξ,4R)-3-acetyl-2-(D_r-1c_F,2c_F,3r_F,4-tetraacetoxy-but-cat_F-yl)-thiazolidine-4-carboxylic acid

Refernces

• 1、 -. "Method to enhance delivery of glutathione and ATP levels in cells". Page/Page column 3. . Retrieved 2008/06/13.