1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS No.: 235109-63-4
• Molecular Formula: C16H22ClNO3
• Molecular Weight: 311.809
• Mol file: 235109-63-4.mol

Synonyms:

Chemical Property of 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

Chemical Property:

• PSA: 49.77000
• LogP: 3.49640

Purity/Quality:

99% ^*data from raw suppliers

1-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

There total 10 articles about 1-N-BOC-4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(4-chlorophenyl)-4-hydroxypiperidine (39512-49-7) + di-tert-butyl dicarbonate (24424-99-5) → 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (235109-63-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1002/chem.201903702

Reference yield: 78.0%

1-Chloro-4-iodobenzene (637-87-6) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (235109-63-4)

Guidance literature:

1-Chloro-4-iodobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield: 74.0%

bromochlorobenzene (106-39-8) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (235109-63-4)

Guidance literature:

bromochlorobenzene; N-tert-butyloxycarbonylpiperidin-4-one; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃;

With ammonium chloride; In tetrahydrofuran; hexanes; water;

upstream raw materials:

bromochlorobenzene

N-tert-butyloxycarbonylpiperidin-4-one

(4-chlorphenyl)magnesium bromide

4-(4-chlorophenyl)-4-hydroxypiperidine

Downstream raw materials:

4-(4-chlorophenyl)-4-hydroxypiperidine

4-(4-chloro-phenyl)-4-methoxy-piperidine

tert-butyl 4-(4-chlorophenyl)piperidine-1-carboxylate

4-(4-chlorophenyl)piperidine

Refernces

• 1、 Aguilar Troyano, Francisco José,Ballaschk, Frederic,Jaschinski, Marcel,?zkaya, Yasemin,Gómez-Suárez, Adrián. "Light-Mediated Formal Radical Deoxyfluorination of Tertiary Alcohols through Selective Single-Electron Oxidation with TEDA2+.". supporting information. p. 14054 - 14058. Retrieved 2019/11/11.
• 2、 Greb, Andreas,Poh, Jian-Siang,Greed, Stephanie,Battilocchio, Claudio,Pasau, Patrick,Blakemore, David C.,Ley, Steven V.. "A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions". . p. 16602 - 16605. Retrieved 2017/12/13.