8-Hydroxyoctadecanoic acid methyl ester

Base Information

• Chemical Name: 8-Hydroxyoctadecanoic acid methyl ester
• CAS No.: 2379-98-8
• Molecular Formula: C19H38O3
• Molecular Weight: 314.509
• Hs Code.: 2918199090
• Mol file: 2379-98-8.mol

Synonyms:(+/-)-8-Hydroxy-octadecansaeure-methylester;8-Hydroxy-octadecansaeuremethylester;methyl 8-hydroxystearate;8-Hydroxy-octadecansaeure-methylester;8(R)-Hydroxyoctadecanoic Acid;8-hydroxy-octadecanoic acid methyl ester;d,l-8-Hydroxy-octadecansaeure-methylester;

Chemical Property of 8-Hydroxyoctadecanoic acid methyl ester

Chemical Property:

• PSA: 46.53000
• LogP: 5.39170

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Hydroxyoctadecanoic acid methyl ester

There total 14 articles about 8-Hydroxyoctadecanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-bromo dodecane (112-29-8) + methyl 8-oxooctanoate (3884-92-2) → methyl 8-hydroxyoctadecanoate (2379-98-8)

Guidance literature:

1-bromo dodecane; With magnesium; ethylene dibromide; In tetrahydrofuran; at 70 ℃; Inert atmosphere;

methyl 8-oxooctanoate; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield:

8-hydroxy-trans-11,17-octadecadien-9-ynoic acid methyl ester (5760-41-8,20715-00-8) → methyl 8-hydroxyoctadecanoate (2379-98-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jo01340a042

Reference yield:

8-hydroxy-trans-11,17-octadecadien-9-ynoic acid (20714-97-0) → methyl 8-hydroxyoctadecanoate (2379-98-8)

Guidance literature:

Multi-step reaction with 2 steps

2: H₂ / Pd-C / acetic acid

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jo01340a042

upstream raw materials:

(+/-)-8-hydroxy-octadec-11c-en-9-ynoic acid methyl ester

8-hydroxy-trans-11-octadecen-9-ynoic acid methyl ester

methyl 8-ketooctadecanoate

8-hydroxyoctadecanoic acid

Downstream raw materials:

methyl 8-ketooctadecanoate

8-hydroxyoctadecanoic acid

8-hydroxyoctadecanoic acid

(3-((8-(1H-imidazol-1-yl)octadecanoyl)oxy)propyl)triphenylphosphonium bromide

Refernces

• 1、 Ebert, Cynthia,Felluga, Fulvia,Forzato, Cristina,Foscato, Marco,Gardossi, Lucia,Nitti, Patrizia,Pitacco, Giuliana,Boga, Carla,Caruana, Paolo,Micheletti, Gabriele,Calonghi, Natalia,Masotti, Lanfranco. "Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation". . p. 38 - 45. Retrieved 2012/11/07.
• 2、 Ahmad, Mohammad Shamim,Rauf, Abdul,Mustafa, Jamal,Osman, Sheikh Mohammad. "AN 8-HYDROXYOCTADECA-CIS-11,14-DIENOIC ACID FROM MIRABILIS JALAPA SEED OIL". . p. 2247 - 2250. Retrieved 2007/10/02.