3,4-DICHLOROPHENETHYL ALCOHOL

Base Information

• Chemical Name: 3,4-DICHLOROPHENETHYL ALCOHOL
• CAS No.: 35364-79-5
• Molecular Formula: C8H8Cl2O
• Molecular Weight: 191.057
• Hs Code.: 29062990
• Mol file: 35364-79-5.mol

Synonyms:Phenethylalcohol, 3,4-dichloro- (6CI,7CI,8CI);b-(3,4-Dichlorophenyl)ethanol;NSC 55518;

Chemical Property of 3,4-DICHLOROPHENETHYL ALCOHOL

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 0.00196mmHg at 25°C
• Refractive Index: 1.562-1.568
• Boiling Point: 279.118 °C at 760 mmHg
• Flash Point: 117.921 °C
• PSA: 20.23000
• Density: 1.33 g/cm³
• LogP: 2.52820
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(3,4-Dichlorophenyl)ethanol >96.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41-51-36/37/38-20/21/22
• Safety Statements: 24/25-39-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the synthesis of σ receptor ligands.

Technology Process of 3,4-DICHLOROPHENETHYL ALCOHOL

There total 9 articles about 3,4-DICHLOROPHENETHYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dichlorophenyl acetic acid (5807-30-7) → 2-(3,4-dichlorophenyl)ethanol (35364-79-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 12h; Heating;

DOI:10.1021/jm0604528

Reference yield: 92.0%

C14H22Cl2OSi → 2-(3,4-dichlorophenyl)ethanol (35364-79-5)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane; at 20 - 25 ℃; for 0.333333h; Flow reactor;

DOI:10.1016/j.tetlet.2017.05.008

Reference yield: 89.0%

→ 2-(3,4-dichlorophenyl)ethanol (35364-79-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

3,4-dichlorophenyl acetic acid

2-(3,4-dichlorophenyl)ethanamine

ethyl 3,4-dichlorophenylacetate

2-(3,4-dichlorophenyl)oxirane

Downstream raw materials:

(3,4-dichloro-phenethyl)-hydrazine

diethyl 2-acetamido-2-(4,5-dichloro-2-(2-cyanoethyl)benzyl)malonate

2-(3,4-dichlorophenyl)ethyl chloride

1-iodo-2-(3,4-dichlorophenyl)ethane

Refernces

• 1、 -. "NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF". Paragraph 00124. . Retrieved 2021/11/13.
• 2、 Son, Woo Seung,Jeong, Kyu-Sung,Lim, Sang Min,Pae, Ae Nim. "Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model". supporting information. p. 1168 - 1172. Retrieved 2019/03/28.