2,4-Dichloro-6-methoxy-1,3,5-triazine

Base Information

• Chemical Name: 2,4-Dichloro-6-methoxy-1,3,5-triazine
• CAS No.: 3638-04-8
• Molecular Formula: C4H3Cl2N3O
• Molecular Weight: 179.993
• Hs Code.: 2933699090
• European Community (EC) Number: 222-863-4
• NSC Number: 50574
• UNII: WG2YE7S694
• DSSTox Substance ID: DTXSID60189906
• Nikkaji Number: J33.219D
• Wikidata: Q72466722
• Mol file: 3638-04-8.mol

Synonyms:2,4-Dichloro-6-methoxy-1,3,5-triazine;3638-04-8;1,3,5-Triazine, 2,4-dichloro-6-methoxy-;2,4-Dichloro-6-methoxy-3,5-triazine;WG2YE7S694;MFCD00128159;NSC-50574;2,4-DICHLORO-6-METHOXY-S-TRIAZINE;C4H3Cl2N3O;NSC50574;UNII-WG2YE7S694;SCHEMBL329417;DTXSID60189906;2-methoxy-4,6-dichloro-s-triazine;2,4 Dichloro-6-methoxy-S-triazine;EINECS 222-863-4;NSC 50574;1-(4-bromo-thiophen-2-yl)-ethanone;2-Methoxy[4,6-dichloro-S-triazine];AKOS009159381;SB73711;AS-63090;SY107505;2-methoxy-4,6-dichloro-1,3,5-triazine;2,4-dichloro-6-methoxy-[1,3,5]triazine;CS-0030450;EN300-65823;2,4-Dichloro-6-methoxy-1,3,5-triazine DCMT;A913769;4,6-Dichloro-1,3,5-triazin-2-yl methyl ether #

Chemical Property of 2,4-Dichloro-6-methoxy-1,3,5-triazine

Chemical Property:

• Appearance/Colour: WHITE POWDER OR CRYSTALS
• Vapor Pressure: 0.00022mmHg at 25°C
• Melting Point: 86-88 °C(lit.)
• Refractive Index: 1.545
• Boiling Point: 336.3 °C at 760 mmHg
• PKA: -1.40±0.10(Predicted)
• Flash Point: 157.2 °C
• PSA: 47.90000
• Density: 1.538 g/cm³
• LogP: 1.18700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 178.9653171
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloro-6-methoxy-1,3,5-triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=NC(=NC(=N1)Cl)Cl
• Uses: 2,4-Dichloro-6-methoxy-1,3,5-triazine was used as reagent in radioimmunoassay for D-Ala2-Dermorphin, a natural peptide extracted from amphibian skin. It was also used in the preparation of:α-cyclodextrin [2]-rotaxanessubstituted s-triazinesseries of chiral derivatizing reagents

Technology Process of 2,4-Dichloro-6-methoxy-1,3,5-triazine

There total 5 articles about 2,4-Dichloro-6-methoxy-1,3,5-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 1,3,5-trichloro-2,4,6-triazine (108-77-0) → 2,4-Dichloro-6-methoxy-1,3,5-triazine (3638-04-8)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 ℃; for 2.5h;

DOI:10.3987/COM-08-S(D)24

Reference yield: 82.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + sodium methylate (124-41-4) → 2,4-Dichloro-6-methoxy-1,3,5-triazine (3638-04-8) + 2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6)

Guidance literature:

In methanol; toluene; at 0 ℃; for 2h;

DOI:10.1039/a908816d

Reference yield:

1,3,5-trichloro-2,4,6-triazine (108-77-0) → 2,4-Dichloro-6-methoxy-1,3,5-triazine (3638-04-8)

Guidance literature:

With sodium hydrogencarbonate; In methanol; (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

methanol

1,3,5-trichloro-2,4,6-triazine

sodium methylate

thiophenol

Downstream raw materials:

2-amino-4-chloro-6-methoxy-1,3,5-triazine

S-ethyl 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)-phenyl]-2-(4-methoxy-6-chloro-1,3,5-triazin-2-ylamino)propionate

methyl 2-(4-chloro-6-methoxy-1,3,5-triazin-2-yl)oxy benzoate

C₁₈H₁₁N₅O₉

Refernces

• 1、 Sun, Daekyu,Melman, Galina,LeTourneau, Nickolas J.,Hays, Allison M.,Melman, Artem. "Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine family". . p. 458 - 460. Retrieved 2010.
• 2、 Celik, Derya,Kose, Muhammet. "Triazine based Mn (II) and Mn (II)/Ln (III) complexes: Synthesis, characterization and catecholase activities". . . Retrieved 2019.
• 3、 Soliman, Saied M.,El-Faham, Ayman,Elsilk, Sobhy E.,Farooq, Muhammad. "Two heptacoordinated manganese(II) complexes of giant pentadentate s-triazine bis-Schiff base ligand: Synthesis, crystal structure, biological and DFT studies". . p. 275 - 285. Retrieved 2018.
• 4、 Morandini, Andrea,Leonetti, Benedetta,Riello, Pietro,Sole, Roberto,Gatto, Vanessa,Caligiuri, Isabella,Rizzolio, Flavio,Beghetto, Valentina. "Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts". supporting information. p. 3172 - 3176. Retrieved 2021/08/03.
• 5、 Huang, Huei-Chin,Wu, Chun-Guey. "Synthesis and kinetic study of a series of chloro- and m-carboxypyridium triazinyl reactive dyes". . . Retrieved 2021/02/12.